PDB entry 4cq8

View 4cq8 on RCSB PDB site
Description: Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) in complex with Genz-669178
Class: oxidoreductase
Keywords: oxidoreductase, dhodh
Deposited on 2014-02-12, released 2014-04-30
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-05-08, with a file datestamp of 2019-05-03.
Experiment type: XRAY
Resolution: 1.98 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dihydroorotate dehydrogenase
    Species: Plasmodium falciparum [TaxId:5833]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q54A96 (245-End)
      • expression tag (16-18)
    Domains in SCOPe 2.08: d4cq8a1, d4cq8a2
  • Chain 'B':
    Compound: dihydroorotate dehydrogenase
    Species: Plasmodium falciparum [TaxId:5833]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q54A96 (245-End)
      • expression tag (16-18)
    Domains in SCOPe 2.08: d4cq8b1, d4cq8b2
  • Heterogens: FMN, ORO, JBW, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4cq8A (A:)
mghhhhhhaenlyfqgadpfesynpefflydiflkfclkyidgeichdlflllgkynilp
ydtsndsiyactnikhldfinpfgvaagfdkngvcidsilklgfsfieigtitprgqtgn
akprifrdvesrsiinscgfnnmgcdkvtenlilfrkrqeedkllskhivgvsigknkdt
vnivddlkycinkigryadyiainvsspntpglrdnqeagklkniilsvkeeidnleknn
imndeflwfnttkkkplvfvklapdlnqeqkkeiadvlletnidgmiisntttqindiks
fenkkggvsgaklkdistkficemynytnkqipiiasggifsgldalekieagasvcqly
sclvfngmksavqikrelnhllyqrgyynlkeaigrkhsks

    Sequence, based on observed residues (ATOM records): (download) 
    >4cq8A (A:)
adpfesynpefflydiflkfclkyidgeichdlflllgkynilpydtsndsiyactnikh
ldfinpfgvaagfdkngvcidsilklgfsfieigtitprgqtgnakprifrdvesrsiin
scgfnnmgcdkvtenlilfrkrqeedkllskhivgvsigknkdtvnivddlkycinkigr
yadyiainvsspntpglrdnqeagklkniilsvkeeidnleknnflwfnttkkkplvfvk
lapdlnqeqkkeiadvlletnidgmiisntttqindiksfenkkggvsgaklkdistkfi
cemynytnkqipiiasggifsgldalekieagasvcqlysclvfngmksavqikrelnhl
lyqrgyynlkeaigrkhs

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4cq8B (B:)
mghhhhhhaenlyfqgadpfesynpefflydiflkfclkyidgeichdlflllgkynilp
ydtsndsiyactnikhldfinpfgvaagfdkngvcidsilklgfsfieigtitprgqtgn
akprifrdvesrsiinscgfnnmgcdkvtenlilfrkrqeedkllskhivgvsigknkdt
vnivddlkycinkigryadyiainvsspntpglrdnqeagklkniilsvkeeidnleknn
imndeflwfnttkkkplvfvklapdlnqeqkkeiadvlletnidgmiisntttqindiks
fenkkggvsgaklkdistkficemynytnkqipiiasggifsgldalekieagasvcqly
sclvfngmksavqikrelnhllyqrgyynlkeaigrkhsks

    Sequence, based on observed residues (ATOM records): (download) 
    >4cq8B (B:)
adpfesynpefflydiflkfclkyidgeichdlflllgkynilpydtsndsiyactnikh
ldfinpfgvaagfdkngvcidsilklgfsfieigtitprgqtgnakprifrdvesrsiin
scgfnnmgcdkvtenlilfrkrqeedkllskhivgvsigknkdtvnivddlkycinkigr
yadyiainvsspntpglrdnqeagklkniilsvkeeidnleknnflwfnttkkkplvfvk
lapdlnqeqkkeiadvlletnidgmiisntttqindiksfenkkggvsgaklkdistkfi
cemynytnkqipiiasggifsgldalekieagasvcqlysclvfngmksavqikrelnhl
lyqrgyynlkeaigrkhs