PDB entry 4cp7
View 4cp7 on RCSB PDB site
Description: Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol
Class: hydrolase
Keywords: hydrolase, inhibitor, rational drug design, enzyme
Deposited on
2014-01-31, released
2014-12-10
The last revision prior to the SCOPe 2.08 freeze date was dated
2018-01-17, with a file datestamp of
2018-01-12.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: N/A
AEROSPACI score: 0.37
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Protease
Species: HUMAN IMMUNODEFICIENCY VIRUS [TaxId:12721]
Database cross-references and differences (RAF-indexed):
- Uniprot P03366
- engineered mutation (62)
- engineered mutation (81)
- engineered mutation (83)
Domains in SCOPe 2.08: d4cp7a_ - Chain 'B':
Compound: Protease
Species: HUMAN IMMUNODEFICIENCY VIRUS [TaxId:12721]
Database cross-references and differences (RAF-indexed):
- Uniprot P03366 (0-98)
- engineered mutation (62)
- engineered mutation (81)
- engineered mutation (83)
Domains in SCOPe 2.08: d4cp7b_ - Heterogens: CL, 9MW, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>4cp7A (A:)
pqitlwqrplvtikiggqlkealldtgaddtvleemslpgrwkpkmiggiggfikvrqyd
qipieicghkaigtvlvgptptnvigrnlltqigctlnf
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>4cp7B (B:)
pqitlwqrplvtikiggqlkealldtgaddtvleemslpgrwkpkmiggiggfikvrqyd
qipieicghkaigtvlvgptptnvigrnlltqigctlnf