PDB entry 4cnh

View 4cnh on RCSB PDB site
Description: Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor 3-((1R)-1-(5-fluoro-2-methoxyphenyl)ethoxy)-5-(1-methyl-1H- 1,2,3-triazol-5-yl)pyridin-2-amine
Class: transferase
Keywords: transferase, receptor tyrosine kinase, inhibitor
Deposited on 2014-01-22, released 2014-05-28
The last revision prior to the SCOPe 2.07 freeze date was dated 2014-06-25, with a file datestamp of 2014-06-20.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.206
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ALK tyrosine kinase receptor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4cnha_
  • Chain 'B':
    Compound: ALK tyrosine kinase receptor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4cnhb_
  • Heterogens: 3U9, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4cnhA (A:)
mahhhhhhnpnycfagktssisdlkevprknitlirglghgafgevyegqvsgmpndpsp
lqvavktlpevcseqdeldflmealiiskfnhqnivrcigvslqslprfillelmaggdl
ksflretrprpsqpsslamldllhvardiacgcqyleenhfihrdiaarnclltcpgpgr
vakigdfgmardiyrasyyrkggcamlpvkwmppeafmegiftsktdtwsfgvllweifs
lgympypsksnqevlefvtsggrmdppkncpgpvyrimtqcwqhqpedrpnfaiilerie
yctqdpdvintalpieygplveeeekv

    Sequence, based on observed residues (ATOM records): (download) 
    >4cnhA (A:)
pnycfagktssisdlkevprknitlirglevyegqvsplqvavktlpevcseqdeldflm
ealiiskfnhqnivrcigvslqslprfillelmaggdlksflretrprpsqpsslamldl
lhvardiacgcqyleenhfihrdiaarnclltcpgpgrvakigdfgmardiyrmlpvkwm
ppeafmegiftsktdtwsfgvllweifslgympypsksnqevlefvtsggrmdppkncpg
pvyrimtqcwqhqpedrpnfaiilerieyctqdpdvintalpieyg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4cnhB (B:)
mahhhhhhnpnycfagktssisdlkevprknitlirglghgafgevyegqvsgmpndpsp
lqvavktlpevcseqdeldflmealiiskfnhqnivrcigvslqslprfillelmaggdl
ksflretrprpsqpsslamldllhvardiacgcqyleenhfihrdiaarnclltcpgpgr
vakigdfgmardiyrasyyrkggcamlpvkwmppeafmegiftsktdtwsfgvllweifs
lgympypsksnqevlefvtsggrmdppkncpgpvyrimtqcwqhqpedrpnfaiilerie
yctqdpdvintalpieygplveeeekv

    Sequence, based on observed residues (ATOM records): (download) 
    >4cnhB (B:)
npnycfagktssisdlkevprknitlirglghgafgevyegqvsplqvavktlpevcseq
deldflmealiiskfnhqnivrcigvslqslprfillelmaggdlksflretrprpssla
mldllhvardiacgcqyleenhfihrdiaarnclltcpgpgrvakigdfgmardiyrasy
camlpvkwmppeafmegiftsktdtwsfgvllweifslgympypsksnqevlefvtsggr
mdppkncpgpvyrimtqcwqhqpedrpnfaiilerieyctqdpdvintalpiey