PDB entry 4cmp

View 4cmp on RCSB PDB site
Description: Crystal structure of S. pyogenes Cas9
Class: hydrolase
Keywords: hydrolase, DNAse, RNA-guided, immunity, crrna, genome editing
Deposited on 2014-01-16, released 2014-02-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-03-26, with a file datestamp of 2014-03-21.
Experiment type: XRAY
Resolution: 2.62 Å
R-factor: 0.2532
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: crispr-associated endonuclease cas9/csn1
    Species: Streptococcus pyogenes [TaxId:301447]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4cmpa1, d4cmpa2, d4cmpa3, d4cmpa4
  • Chain 'B':
    Compound: crispr-associated endonuclease cas9/csn1
    Species: Streptococcus pyogenes [TaxId:301447]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4cmpb1, d4cmpb2, d4cmpb3, d4cmpb4
  • Heterogens: SO4, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4cmpA (A:)
    gaasmdkkysigldigtnsvgwavitdeykvpskkfkvlgntdrhsikknligallfdsg
    etaeatrlkrtarrrytrrknricylqeifsnemakvddsffhrleesflveedkkherh
    pifgnivdevayhekyptiyhlrkklvdstdkadlrliylalahmikfrghfliegdlnp
    dnsdvdklfiqlvqtynqlfeenpinasgvdakailsarlsksrrlenliaqlpgekkng
    lfgnlialslgltpnfksnfdlaedaklqlskdtydddldnllaqigdqyadlflaaknl
    sdaillsdilrvnteitkaplsasmikrydehhqdltllkalvrqqlpekykeiffdqsk
    ngyagyidggasqeefykfikpilekmdgteellvklnredllrkqrtfdngsiphqihl
    gelhailrrqedfypflkdnrekiekiltfripyyvgplargnsrfawmtrkseetitpw
    nfeevvdkgasaqsfiermtnfdknlpnekvlpkhsllyeyftvyneltkvkyvtegmrk
    paflsgeqkkaivdllfktnrkvtvkqlkedyfkkiecfdsveisgvedrfnaslgtyhd
    llkiikdkdfldneenediledivltltlfedremieerlktyahlfddkvmkqlkrrry
    tgwgrlsrklingirdkqsgktildflksdgfanrnfmqlihddsltfkediqkaqvsgq
    gdslhehianlagspaikkgilqtvkvvdelvkvmgrhkpeniviemarenqttqkgqkn
    srermkrieegikelgsqilkehpventqlqneklylyylqngrdmyvdqeldinrlsdy
    dvdhivpqsflkddsidnkvltrsdknrgksdnvpseevvkkmknywrqllnaklitqrk
    fdnltkaergglseldkagfikrqlvetrqitkhvaqildsrmntkydendklirevkvi
    tlksklvsdfrkdfqfykvreinnyhhahdaylnavvgtalikkypklesefvygdykvy
    dvrkmiakseqeigkatakyffysnimnffkteitlangeirkrplietngetgeivwdk
    grdfatvrkvlsmpqvnivkktevqtggfskesilpkrnsdkliarkkdwdpkkyggfds
    ptvaysvlvvakvekgkskklksvkellgitimerssfeknpidfleakgykevkkdlii
    klpkyslfelengrkrmlasagelqkgnelalpskyvnflylashyeklkgspedneqkq
    lfveqhkhyldeiieqisefskrviladanldkvlsaynkhrdkpireqaeniihlftlt
    nlgapaafkyfdttidrkrytstkevldatlihqsitglyetridlsqlggd
    

    Sequence, based on observed residues (ATOM records): (download)
    >4cmpA (A:)
    kysigldigtnsvgwavitdeykvpskkfkvlgntdrhsikknligallfdsgetaeatr
    lkrtarrrytrrknricylqeifsnemakvddsffhrlerhpifgnivdevayhekypti
    yhlrkklvdstdkadlrliylalahmikfrghfliegdlnpdnsdvdklfiqlvqtynql
    feenpinasgvdakailsarlsksrrlenliaqlpgekknglfgnlialslgltpnfksn
    fdlaedaklqlskdtydddldnllaqigdqyadlflaaknlsdaillsdilrkaplsasm
    ikrydehhqdltllkalvrqqlpekykeiffdqskngyagyidggasqeefykfikpile
    kmdgteellvklnredllrkqrtfdngsiphqihlgelhailrrqedfypflkdnrekie
    kiltfrpnekvlpkhsllyeyftvyneltkvlsgeqkkaivdllfktnrkvtvkqlkedf
    naslgtyhdllkiikdkdfldneenediledivltltlfedremieerlktyahlfddkv
    mkqlkrrrytgwgrlsrklingirdktildflkrnfmqlihddsltfkediqkaqvsdsl
    hehianlagspaikkgilqtvkvvdelvkvmgrhkpeniviemaknsrermkrieegike
    lhpventqlqneklylyylqngrdmyvdqeldinrlsdydvdhivpqsflkddsidnkvl
    trknrgksdnvpseevvkkmknywrqllnaklitqrkfdnltklseldkagfikrqlvet
    rqitkhvaqildsrmntkydendklirevkvitlksklvsdfrkdfqfykvreinnyhha
    hdaylnavvgtalikkypklesefvygdykvydvrkmiakseqyffysnimnffkteitl
    angeirkrplietngetgeivwdkgrdfatvrkvlsmpqvnivkktevqtptvaysvlvv
    svkellgitimerssfeknpidfleakgkdliiklpkyslfelengrkrmlasagelqkg
    nelalpskyvnflylashyveqhkhyldeiieqisefskrviladanldkvlsaynkhrd
    kpireqaeniihlftltnlgapaafkyfdttidrkrytstkevldatlihqsitglyetr
    idls
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4cmpB (B:)
    gaasmdkkysigldigtnsvgwavitdeykvpskkfkvlgntdrhsikknligallfdsg
    etaeatrlkrtarrrytrrknricylqeifsnemakvddsffhrleesflveedkkherh
    pifgnivdevayhekyptiyhlrkklvdstdkadlrliylalahmikfrghfliegdlnp
    dnsdvdklfiqlvqtynqlfeenpinasgvdakailsarlsksrrlenliaqlpgekkng
    lfgnlialslgltpnfksnfdlaedaklqlskdtydddldnllaqigdqyadlflaaknl
    sdaillsdilrvnteitkaplsasmikrydehhqdltllkalvrqqlpekykeiffdqsk
    ngyagyidggasqeefykfikpilekmdgteellvklnredllrkqrtfdngsiphqihl
    gelhailrrqedfypflkdnrekiekiltfripyyvgplargnsrfawmtrkseetitpw
    nfeevvdkgasaqsfiermtnfdknlpnekvlpkhsllyeyftvyneltkvkyvtegmrk
    paflsgeqkkaivdllfktnrkvtvkqlkedyfkkiecfdsveisgvedrfnaslgtyhd
    llkiikdkdfldneenediledivltltlfedremieerlktyahlfddkvmkqlkrrry
    tgwgrlsrklingirdkqsgktildflksdgfanrnfmqlihddsltfkediqkaqvsgq
    gdslhehianlagspaikkgilqtvkvvdelvkvmgrhkpeniviemarenqttqkgqkn
    srermkrieegikelgsqilkehpventqlqneklylyylqngrdmyvdqeldinrlsdy
    dvdhivpqsflkddsidnkvltrsdknrgksdnvpseevvkkmknywrqllnaklitqrk
    fdnltkaergglseldkagfikrqlvetrqitkhvaqildsrmntkydendklirevkvi
    tlksklvsdfrkdfqfykvreinnyhhahdaylnavvgtalikkypklesefvygdykvy
    dvrkmiakseqeigkatakyffysnimnffkteitlangeirkrplietngetgeivwdk
    grdfatvrkvlsmpqvnivkktevqtggfskesilpkrnsdkliarkkdwdpkkyggfds
    ptvaysvlvvakvekgkskklksvkellgitimerssfeknpidfleakgykevkkdlii
    klpkyslfelengrkrmlasagelqkgnelalpskyvnflylashyeklkgspedneqkq
    lfveqhkhyldeiieqisefskrviladanldkvlsaynkhrdkpireqaeniihlftlt
    nlgapaafkyfdttidrkrytstkevldatlihqsitglyetridlsqlggd
    

    Sequence, based on observed residues (ATOM records): (download)
    >4cmpB (B:)
    kysigldigtnsvgwavitdeykvpskkfkvlgntdrhsikknligallfdsgetaeatr
    lkrtarrrytrrknricylqeifsnemakvddsffhrleehpifgnivdevayhekypti
    yhlrkklvdstdkadlrliylalahmikfrghfliegdlnpdnsdvdklfiqlvqtynql
    feenpinasgvdakailsarlsksrrlenliaqlpgekknglfgnlialslgltpnfksn
    fdlaedaklqlskdtydddldnllaqigdqyadlflaaknlsdaillsdilrvteitkap
    lsasmikrydehhqdltllkalvrqqlpekykeiffdqskngyagyidggasqeefykfi
    kpilekmdgteellvklnredllrkqrtfdngsiphqihlgelhailrrqedfypflkdn
    rekiekiltfrlpnekvlpkhsllyeyftvyneltkvflsgeqkkaivdllfktnrkvtv
    kqlkedyfkfnaslgtyhdllkiikdkdfldneenediledivltltlfedremieerlk
    tyahlfddkvmkqlkrrrytgwgrlsrklingirdkgktildflksdgfanrnfmqlihd
    dsltfkediqkaqvdslhehianlagspaikkgilqtvkvvdelvkvmgrhkpeniviem
    agqknsrermkrieegikelpventqlqneklylyylqngrdmyvdqeldinrlsdydvd
    hivpqsflkddsidnkvltrknrgksdnvpseevvkkmknywrqllnaklitqrkfdnlt
    klseldkagfikrqlvetrqitkhvaqildsrmntkydendklirevkvitlksklvsdf
    rkdfqfykvreinnyhhahdaylnavvgtalikkypklesefvygdykvydvrkmiaksy
    ffysnimnffkteitlangeirkrplietngetgeivwdkgrdfatvrkvlsmpqvnivk
    ktevqtptvaysvlvvakvkellgitimerssfeknpidfleakkevkkdliiklpkysl
    felengrkrmlasagelqkgnelalpskyvnflylashqlfveqhkhyldeiieqisefs
    krviladanldkvlsaynkhrdkpireqaeniihlftltnlgapaafkyfdttidrkryt
    stkevldatlihqsitglyetridls