PDB entry 4cmo

View 4cmo on RCSB PDB site
Description: Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor 2-((1R)-1-((3-amino-6-(2-methoxypyridin-3-yl)pyrazin-2-yl) oxy)ethyl)-4-fluoro-N-methylbenzamide
Class: transferase
Keywords: transferase, receptor tyrosine kinase inhibitor
Deposited on 2014-01-16, released 2014-05-28
The last revision prior to the SCOPe 2.05 freeze date was dated 2014-06-25, with a file datestamp of 2014-06-20.
Experiment type: XRAY
Resolution: 1.83 Å
R-factor: 0.199
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ALK tyrosine kinase receptor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4cmoa_
  • Heterogens: YPW, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4cmoA (A:)
    mahhhhhhnpnycfagktssisdlkevprknitlirglghgafgevyegqvsgmpndpsp
    lqvavktlpevcseqdeldflmealiiskfnhqnivrcigvslqslprfillelmaggdl
    ksflretrprpsqpsslamldllhvardiacgcqyleenhfihrdiaarnclltcpgpgr
    vakigdfgmardiyrasyyrkggcamlpvkwmppeafmegiftsktdtwsfgvllweifs
    lgympypsksnqevlefvtsggrmdppkncpgpvyrimtqcwqhqpedrpnfaiilerie
    yctqdpdvintalpieygplveeeekv
    

    Sequence, based on observed residues (ATOM records): (download)
    >4cmoA (A:)
    npnycfagktssisdlkevprknitlirglghgafgevyegqvplqvavktlpevcseqd
    eldflmealiiskfnhqnivrcigvslqslprfillelmaggdlksflretrprpsqpss
    lamldllhvardiacgcqyleenhfihrdiaarnclltcpgpgrvakigdfgmardiyrg
    gcamlpvkwmppeafmegiftsktdtwsfgvllweifslgympypsksnqevlefvtsgg
    rmdppkncpgpvyrimtqcwqhqpedrpnfaiilerieyctqdpdvintalpieyg