PDB entry 4clx

View 4clx on RCSB PDB site
Description: Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor
Class: oxidoreductase
Keywords: oxidoreductase, short-chain dehydrogenase/reductase
Deposited on 2014-01-15, released 2015-01-21
The last revision prior to the SCOPe 2.05 freeze date was dated 2015-01-21, with a file datestamp of 2015-01-16.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: 0.14569
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: pteridine reductase 1
    Species: Trypanosoma brucei brucei [TaxId:5702]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4clxa_
  • Chain 'B':
    Compound: pteridine reductase 1
    Species: Trypanosoma brucei brucei [TaxId:5702]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4clxb_
  • Chain 'C':
    Compound: pteridine reductase 1
    Species: Trypanosoma brucei brucei [TaxId:5702]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4clxc_
  • Chain 'D':
    Compound: pteridine reductase 1
    Species: Trypanosoma brucei brucei [TaxId:5702]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4clxd_
  • Heterogens: NAP, Q0K, ACT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4clxA (A:)
mgsshhhhhhssglvprgshmeapaavvtgaakrigraiavklhqtgyrvvihyhnsaea
avsladelnkersntavvcqadltnsnvlpasceeiinscfrafgrcdvlvnnasafypt
plvqgdhednsngktvetqvaeligtnaiapflltmsfaqrqkgtnpnctssnlsivnlc
damvdqpcmafslynmgkhalvgltqsaalelapygirvngvapgvsllpvamgeeekdk
wrrkvplgrreasaeqiadaviflvsgsaqyitgsiikvdgglslvha

    Sequence, based on observed residues (ATOM records): (download) 
    >4clxA (A:)
eapaavvtgaakrigraiavklhqtgyrvvihyhnsaeaavsladelnkersntavvcqa
dltnsnvlpasceeiinscfrafgrcdvlvnnasafyptplvqgktvetqvaeligtnai
apflltmsfaqrqssnlsivnlcdamvdqpcmafslynmgkhalvgltqsaalelapygi
rvngvapgvsllpvamgeeekdkwrrkvplgrreasaeqiadaviflvsgsaqyitgsii
kvdgglslvha

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4clxB (B:)
mgsshhhhhhssglvprgshmeapaavvtgaakrigraiavklhqtgyrvvihyhnsaea
avsladelnkersntavvcqadltnsnvlpasceeiinscfrafgrcdvlvnnasafypt
plvqgdhednsngktvetqvaeligtnaiapflltmsfaqrqkgtnpnctssnlsivnlc
damvdqpcmafslynmgkhalvgltqsaalelapygirvngvapgvsllpvamgeeekdk
wrrkvplgrreasaeqiadaviflvsgsaqyitgsiikvdgglslvha

    Sequence, based on observed residues (ATOM records): (download) 
    >4clxB (B:)
eapaavvtgaakrigraiavklhqtgyrvvihyhnsaeaavsladelnkersntavvcqa
dltnsnvlpasceeiinscfrafgrcdvlvnnasafyptplvgktvetqvaeligtnaia
pflltmsfaqrqssnlsivnlcdamvdqpcmafslynmgkhalvgltqsaalelapygir
vngvapgvsllpvamgeeekdkwrrkvplgrreasaeqiadaviflvsgsaqyitgsiik
vdgglslvha

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4clxC (C:)
mgsshhhhhhssglvprgshmeapaavvtgaakrigraiavklhqtgyrvvihyhnsaea
avsladelnkersntavvcqadltnsnvlpasceeiinscfrafgrcdvlvnnasafypt
plvqgdhednsngktvetqvaeligtnaiapflltmsfaqrqkgtnpnctssnlsivnlc
damvdqpcmafslynmgkhalvgltqsaalelapygirvngvapgvsllpvamgeeekdk
wrrkvplgrreasaeqiadaviflvsgsaqyitgsiikvdgglslvha

    Sequence, based on observed residues (ATOM records): (download) 
    >4clxC (C:)
eapaavvtgaakrigraiavklhqtgyrvvihyhnsaeaavsladelnkersntavvcqa
dltnsnvlpasceeiinscfrafgrcdvlvnnasafyptplvgktvetqvaeligtnaia
pflltmsfaqrqssnlsivnlcdamvdqpcmafslynmgkhalvgltqsaalelapygir
vngvapgvsllpvamgeeekdkwrrkvplgrreasaeqiadaviflvsgsaqyitgsiik
vdgglslvha

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4clxD (D:)
mgsshhhhhhssglvprgshmeapaavvtgaakrigraiavklhqtgyrvvihyhnsaea
avsladelnkersntavvcqadltnsnvlpasceeiinscfrafgrcdvlvnnasafypt
plvqgdhednsngktvetqvaeligtnaiapflltmsfaqrqkgtnpnctssnlsivnlc
damvdqpcmafslynmgkhalvgltqsaalelapygirvngvapgvsllpvamgeeekdk
wrrkvplgrreasaeqiadaviflvsgsaqyitgsiikvdgglslvha

    Sequence, based on observed residues (ATOM records): (download) 
    >4clxD (D:)
eapaavvtgaakrigraiavklhqtgyrvvihyhnsaeaavsladelnkersntavvcqa
dltnsnvlpasceeiinscfrafgrcdvlvnnasafyptplvgktvetqvaeligtnaia
pflltmsfaqrqkssnlsivnlcdamvdqpcmafslynmgkhalvgltqsaalelapygi
rvngvapgvsllpvamgeeekdkwrrkvplgrreasaeqiadaviflvsgsaqyitgsii
kvdgglslvha