PDB entry 4cjy

View 4cjy on RCSB PDB site
Description: Crystal structure of the human CDK12-cyclinK complex
Class: transferase
Keywords: transferase, kinase
Deposited on 2013-12-23, released 2014-01-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-06-04, with a file datestamp of 2014-05-30.
Experiment type: XRAY
Resolution: 3.15 Å
R-factor: 0.2174
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cyclin-k
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4cjya1, d4cjya2
  • Chain 'B':
    Compound: cyclin-k
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4cjyb1, d4cjyb2
  • Chain 'C':
    Compound: cyclin-dependent kinase 12
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4cjyc_
  • Chain 'D':
    Compound: cyclin-dependent kinase 12
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4cjyd_

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4cjyA (A:)
smsvtsanldhtkpcwywdkkdlahtpsqlegldpatearyrregarfifdvgtrlglhy
dtlatgiiyfhrfymfhsfkqfpryvtgacclflagkveetpkkckdiiktarsllndvq
fgqfgddpkeevmvlerillqtikfdlqvehpyqfllkyakqlkgdknkiqklvqmawtf
vndslcttlslqwepeiiavavmylagrlckfeiqewtskpmyrrwweqfvqdvpvdvle
dichqildlysqgkqqmph

    Sequence, based on observed residues (ATOM records): (download) 
    >4cjyA (A:)
pcwywdkkdlahtpsqlegldpatearyrregarfifdvgtrlglhydtlatgiiyfhrf
ymfhsfkqfpryvtgacclflagkveetpkkckdiiktarsllndvqfgqfgddpkeevm
vlerillqtikfdlqvehpyqfllkyakqlkgdknkiqklvqmawtfvndslcttlslqw
epeiiavavmylagrlckfeiqewtskpmyrrwweqfvqdvpvdvledichqildlysq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4cjyB (B:)
smsvtsanldhtkpcwywdkkdlahtpsqlegldpatearyrregarfifdvgtrlglhy
dtlatgiiyfhrfymfhsfkqfpryvtgacclflagkveetpkkckdiiktarsllndvq
fgqfgddpkeevmvlerillqtikfdlqvehpyqfllkyakqlkgdknkiqklvqmawtf
vndslcttlslqwepeiiavavmylagrlckfeiqewtskpmyrrwweqfvqdvpvdvle
dichqildlysqgkqqmph

    Sequence, based on observed residues (ATOM records): (download) 
    >4cjyB (B:)
pcwywdkkdlahtpsqlegldpatearyrregarfifdvgtrlglhydtlatgiiyfhrf
ymfhsfkqfpryvtgacclflagkveetpkkckdiiktarsllndvqfgqfgddpkeevm
vlerillqtikfdlqvehpyqfllkyakqlkgdknkiqklvqmawtfvndslcttlslqw
epeiiavavmylagrlckfeiqewtskprrwweqfvqdvpvdvledichqildlysq

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4cjyC (C:)
smtesdwgkrcvdkfdiigiigegtygqvykakdkdtgelvalkkvrldnekegfpitai
reikilrqlihrsvvnmkeivtdkqdaldfkkdkgafylvfeymdhdlmgllesglvhfs
edhiksfmkqlmegleychkknflhrdikcsnillnnsgqikladfglarlynseesrpy
tnkvitlwyrppelllgeerytpaidvwscgcilgelftkkpifqanlelaqlelisrlc
gspcpavwpdviklpyfntmkpkkqyrrrlreefsfipsaaldlldhmltldpskrctae
qtlqsdflkdvelskmappdlphwqd

    Sequence, based on observed residues (ATOM records): (download) 
    >4cjyC (C:)
wgkrcvdkfdiigiigegtygqvykakdkdtgelvalkkvrldnekegfpitaireikil
rqlihrsvvnmkeivtdkkdkgafylvfeymdhdlmgllesglvhfsedhiksfmkqlme
gleychkknflhrdikcsnillnnsgqikladfglarlynseesrpytnkvitlwyrppe
lllgeerytpaidvwscgcilgelftkkpifqanlelaqlelisrlcgspcpavwpdvik
lpyfntmkpqyrrrlreefsfipsaaldlldhmltldpskrctaeqtlqsdflkdvelsk
mapp

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4cjyD (D:)
smtesdwgkrcvdkfdiigiigegtygqvykakdkdtgelvalkkvrldnekegfpitai
reikilrqlihrsvvnmkeivtdkqdaldfkkdkgafylvfeymdhdlmgllesglvhfs
edhiksfmkqlmegleychkknflhrdikcsnillnnsgqikladfglarlynseesrpy
tnkvitlwyrppelllgeerytpaidvwscgcilgelftkkpifqanlelaqlelisrlc
gspcpavwpdviklpyfntmkpkkqyrrrlreefsfipsaaldlldhmltldpskrctae
qtlqsdflkdvelskmappdlphwqd

    Sequence, based on observed residues (ATOM records): (download) 
    >4cjyD (D:)
cvdkfdiigiigegtygqvykakdkdtgelvalkkvrlkegfpitaireikilrqlihrs
vvnmkeivtdafylvfeymdhdlmgllhfsedhiksfmkqlmegleychkknflhrdikc
snillnnsgqikladfglarlynpytnkvitlwyrppelllgeerytpaidvwscgcilg
elftkkpifqanlelaqlelisrlcgspcpavwpdviklpyfntmkpkkqyrrrlreefs
fipsaaldlldhmltldpskrctaeqtlqsdfl