PDB entry 4cib

View 4cib on RCSB PDB site
Description: crystal structure of cathepsin a, complexed with compound 2
Class: hydrolase
Keywords: hydrolase, drug discovery, serine carboxypeptidase, cardiovascular drug, heart failure, endothelin, tetrahedral intermediate, covalent inhibitor
Deposited on 2013-12-06, released 2014-02-26
The last revision prior to the SCOPe 2.07 freeze date was dated 2014-04-02, with a file datestamp of 2014-03-28.
Experiment type: XRAY
Resolution: 1.89 Å
R-factor: 0.14484
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: lysosomal protective protein
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P10619 (2-453)
      • expression tag (1)
      • expression tag (454)
    Domains in SCOPe 2.07: d4ciba1, d4ciba2, d4ciba3
  • Heterogens: 7UZ, CD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4cibA (A:)
srapdqdeiqrlpglakqpsfrqysgylkgsgskhlhywfvesqkdpenspvvlwlnggp
gcssldglltehgpflvqpdgvtleynpyswnlianvlylespagvgfsysddkfyatnd
tevaqsnfealqdffrlfpeyknnklfltgesyagiyiptlavlvmqdpsmnlqglavgn
glssyeqndnslvyfayyhgllgnrlwsslqthccsqnkcnfydnkdlecvtnlqevari
vgnsglniynlyapcaggvpshfryekdtvvvqdlgniftrlplkrmwhqallrsgdkvr
mdppctnttaastylnnpyvrkalnipeqlpqwdmcnflvnlqyrrlyrsmnsqylklls
sqkyqillyngdvdmacnfmgdewfvdslnqkmevqrrpwlvkygdsgeqiagfvkefsh
iafltikgaghmvptdkplaaftmfsrflnkqpye

    Sequence, based on observed residues (ATOM records): (download) 
    >4cibA (A:)
rapdqdeiqrlpglakqpsfrqysgylkgsgskhlhywfvesqkdpenspvvlwlnggpg
cssldglltehgpflvqpdgvtleynpyswnlianvlylespagvgfsysddkfyatndt
evaqsnfealqdffrlfpeyknnklfltgesyagiyiptlavlvmqdpsmnlqglavgng
lssyeqndnslvyfayyhgllgnrlwsslqthccsqnkcnfydnkdlecvtnlqevariv
gnsglniynlyapcaggvpsdppctnttaastylnnpyvrkalnipeqlpqwdmcnflvn
lqyrrlyrsmnsqylkllssqkyqillyngdvdmacnfmgdewfvdslnqkmevqrrpwl
vkygsgeqiagfvkefshiafltikgaghmvptdkplaaftmfsrflnkqpye