PDB entry 4cia

View 4cia on RCSB PDB site
Description: Crystal structure of cathepsin A, complexed with compound 1
Class: hydrolase
Keywords: hydrolase, serine carboxypeptidase, cardiovascular drug, heart failure, endothelin, tetrahedral intermediate, covalent inhibitor
Deposited on 2013-12-06, released 2014-02-26
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-06-29.
Experiment type: XRAY
Resolution: 1.98 Å
R-factor: N/A
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: lysosomal protective protein
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P10619 (2-453)
      • expression tag (1)
      • expression tag (454)
    Domains in SCOPe 2.08: d4ciaa1, d4ciaa2, d4ciaa3
  • Heterogens: 6KZ, CD, NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4ciaA (A:)
    srapdqdeiqrlpglakqpsfrqysgylkgsgskhlhywfvesqkdpenspvvlwlnggp
    gcssldglltehgpflvqpdgvtleynpyswnlianvlylespagvgfsysddkfyatnd
    tevaqsnfealqdffrlfpeyknnklfltgesyagiyiptlavlvmqdpsmnlqglavgn
    glssyeqndnslvyfayyhgllgnrlwsslqthccsqnkcnfydnkdlecvtnlqevari
    vgnsglniynlyapcaggvpshfryekdtvvvqdlgniftrlplkrmwhqallrsgdkvr
    mdppctnttaastylnnpyvrkalnipeqlpqwdmcnflvnlqyrrlyrsmnsqylklls
    sqkyqillyngdvdmacnfmgdewfvdslnqkmevqrrpwlvkygdsgeqiagfvkefsh
    iafltikgaghmvptdkplaaftmfsrflnkqpye
    

    Sequence, based on observed residues (ATOM records): (download)
    >4ciaA (A:)
    rapdqdeiqrlpglakqpsfrqysgylkgsgskhlhywfvesqkdpenspvvlwlnggpg
    cssldglltehgpflvqpdgvtleynpyswnlianvlylespagvgfsysddkfyatndt
    evaqsnfealqdffrlfpeyknnklfltgesyagiyiptlavlvmqdpsmnlqglavgng
    lssyeqndnslvyfayyhgllgnrlwsslqthccsqnkcnfydnkdlecvtnlqevariv
    gnsglniynlyapcaggvpmdppctnttaastylnnpyvrkalnipeqlpqwdmcnflvn
    lqyrrlyrsmnsqylkllssqkyqillyngdvdmacnfmgdewfvdslnqkmevqrrpwl
    vkygsgeqiagfvkefshiafltikgaghmvptdkplaaftmfsrflnkqpye