PDB entry 4cfe

View 4cfe on RCSB PDB site
Description: Structure of full length human AMPK in complex with a small molecule activator, a benzimidazole derivative (991)
Class: transferase
Keywords: transferase, nucleotide-binding, staurosporine-binding, serine/threonine-protein kinase, activator, carbohydrate binding module (cbm)
Deposited on 2013-11-14, released 2013-12-25
The last revision prior to the SCOPe 2.05 freeze date was dated 2014-02-12, with a file datestamp of 2014-02-07.
Experiment type: XRAY
Resolution: 3.02 Å
R-factor: 0.2194
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 5'-AMP-activated protein kinase catalytic subunit alpha-2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: 5'-AMP-activated protein kinase subunit beta-1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: 5'-AMP-activated protein kinase catalytic subunit alpha-2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: 5'-AMP-activated protein kinase subunit beta-1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: 5'-amp-activated protein kinase subunit gamma-1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4cfee1, d4cfee2
  • Chain 'F':
    Compound: 5'-amp-activated protein kinase subunit gamma-1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4cfef1, d4cfef2
  • Heterogens: STU, 992, AMP, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4cfeE (E:)
metvissdsspavenehpqetpesnnsvytsfmkshrcydliptssklvvfdtslqvkka
ffalvtngvraaplwdskkqsfvgmltitdfinilhryyksalvqiyeleehkietwrev
ylqdsfkplvcispnaslfdavsslirnkihrlpvidpesgntlyilthkrilkflklfi
tefpkpefmsksleelqigtyaniamvrtttpvyvalgifvqhrvsalpvvdekgrvvdi
yskfdvinlaaektynnldvsvtkalqhrshyfegvlkcylhetletiinrlveaevhrl
vvvdendvvkgivslsdilqalvltggekkp

    Sequence, based on observed residues (ATOM records): (download) 
    >4cfeE (E:)
svytsfmkshrcydliptssklvvfdtslqvkkaffalvtngvraaplwdskkqsfvgml
titdfinilhryyksalvqiyeleehkietwrevylplvcispnaslfdavsslirnkih
rlpvidpesgntlyilthkrilkflklfitefpkpefmsksleelqigtyaniamvrttt
pvyvalgifvqhrvsalpvvdekgrvvdiyskfdvinlaaektynnldvsvtkalqhrsh
yfegvlkcylhetletiinrlveaevhrlvvvdendvvkgivslsdilqalvlt

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >4cfeF (F:)
metvissdsspavenehpqetpesnnsvytsfmkshrcydliptssklvvfdtslqvkka
ffalvtngvraaplwdskkqsfvgmltitdfinilhryyksalvqiyeleehkietwrev
ylqdsfkplvcispnaslfdavsslirnkihrlpvidpesgntlyilthkrilkflklfi
tefpkpefmsksleelqigtyaniamvrtttpvyvalgifvqhrvsalpvvdekgrvvdi
yskfdvinlaaektynnldvsvtkalqhrshyfegvlkcylhetletiinrlveaevhrl
vvvdendvvkgivslsdilqalvltggekkp

    Sequence, based on observed residues (ATOM records): (download) 
    >4cfeF (F:)
svytsfmkshrcydliptssklvvfdtslqvkkaffalvtngvraaplwdskkqsfvgml
titdfinilhryyksalvqiyeleehkietwrevyplvcispnaslfdavsslirnkihr
lpvidpesgntlyilthkrilkflklfitefpkpefmsksleelqigtyaniamvrtttp
vyvalgifvqhrvsalpvvdekgrvvdiyskfdvinlaaektynnldvsvtkalqhrsvl
kcylhetletiinrlveaevhrlvvvdendvvkgivslsdilqalvlt