PDB entry 4cd0

View 4cd0 on RCSB PDB site
Description: Structure of L1196M Mutant Human Anaplastic Lymphoma Kinase in Complex with 2-(5-(6-amino-5-((R)-1-(5-fluoro-2-(2H-1,2,3-triazol-2- yl)phenyl)ethoxy)pyridin-3-yl)-4-methylthiazol-2-yl)propane-1,2-diol
Class: transferase
Keywords: transferase, receptor tyrosine kinase, inhibitor
Deposited on 2013-10-29, released 2014-01-29
The last revision prior to the SCOPe 2.06 freeze date was dated 2014-03-12, with a file datestamp of 2014-03-07.
Experiment type: XRAY
Resolution: 2.23 Å
R-factor: 0.198
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ALK tyrosine kinase receptor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UM73
      • engineered mutation (126)
    Domains in SCOPe 2.06: d4cd0a_
  • Heterogens: AWJ, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4cd0A (A:)
mahhhhhhdygipttenlyfqgsnpnycfagktssisdlkevprknitlirglghgafge
vyegqvsgmpndpsplqvavktlpevcseqdeldflmealiiskfnhqnivrcigvslqs
lprfilmelmaggdlksflretrprpsqpsslamldllhvardiacgcqyleenhfihrd
iaarnclltcpgpgrvakigdfgmardiyrasyyrkggcamlpvkwmppeafmegiftsk
tdtwsfgvllweifslgympypsksnqevlefvtsggrmdppkncpgpvyrimtqcwqhq
pedrpnfaiilerieyctqdpdvintalpieygplveeeekv

    Sequence, based on observed residues (ATOM records): (download) 
    >4cd0A (A:)
pnycfagktssisdlkevprknitlirglghgafgevyegqvsplqvavktlpevcseqd
eldflmealiiskfnhqnivrcigvslqslprfilmelmaggdlksflretrprpsqpss
lamldllhvardiacgcqyleenhfihrdiaarnclltcpgpgrvakigdfgmardiyrg
gcamlpvkwmppeafmegiftsktdtwsfgvllweifslgympypsksnqevlefvtsgg
rmdppkncpgpvyrimtqcwqhqpedrpnfaiilerieyctqdpdvintalpieyg