PDB entry 4ccb

View 4ccb on RCSB PDB site
Description: Structure of the Human Anaplastic Lymphoma Kinase in Complex with 3-((R)-1-(5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)ethoxy)-5-(5-methyl-1H- pyrazol-4-yl)pyridin-2-amine
Class: transferase
Keywords: transferase, receptor tyrosine kinase, anaplastic lymphoma kinase, inhibitor
Deposited on 2013-10-21, released 2014-01-29
The last revision prior to the SCOPe 2.06 freeze date was dated 2014-03-12, with a file datestamp of 2014-03-07.
Experiment type: XRAY
Resolution: 2.03 Å
R-factor: 0.202
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ALK tyrosine kinase receptor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4ccba_
  • Heterogens: OFG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4ccbA (A:)
mahhhhhhnpnycfagktssisdlkevprknitlirglghgafgevyegqvsgmpndpsp
lqvavktlpevcseqdeldflmealiiskfnhqnivrcigvslqslprfillelmaggdl
ksflretrprpsqpsslamldllhvardiacgcqyleenhfihrdiaarnclltcpgpgr
vakigdfgmardiyrasyyrkggcamlpvkwmppeafmegiftsktdtwsfgvllweifs
lgympypsksnqevlefvtsggrmdppkncpgpvyrimtqcwqhqpedrpnfaiilerie
yctqdpdvintalpieygplveeeekv

    Sequence, based on observed residues (ATOM records): (download) 
    >4ccbA (A:)
npnycfagktssisdlkevprknitlirglghgafgevyegqvsplqvavktlpevcseq
deldflmealiiskfnhqnivrcigvslqslprfillelmaggdlksflretrprpsqsl
amldllhvardiacgcqyleenhfihrdiaarnclltcpgpgrvakigdfgmardiyram
lpvkwmppeafmegiftsktdtwsfgvllweifslgympypsksnqevlefvtsggrmdp
pkncpgpvyrimtqcwqhqpedrpnfaiilerieyctqdpdvintalpiey