PDB entry 4cbr

View 4cbr on RCSB PDB site
Description: X-ray structure of the more stable human AGXT triple mutant (AGXT_HEM)
Class: transferase
Keywords: transferase, primary hiperoxaluria type I
Deposited on 2013-10-16, released 2014-07-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-09-03, with a file datestamp of 2014-08-29.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.222
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine--pyruvate aminotransferase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21549
      • engineered mutation (47)
      • engineered mutation (51)
      • engineered mutation (339)
    Domains in SCOPe 2.08: d4cbra_
  • Heterogens: PLP, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4cbrA (A:)
mashkllvtppkallkplsipnqlllgpgpsnlpprimaagglqmighmskemyqimdei
kegiqyvfqtrnpltlvisgsghcaleaalvnvlepgdsflvgangiwgqravdigerig
arvhpmtkdpgghytlqeveeglaqhkpvllflthgesstgvlqpldgfgelchrykcll
lvdsvaslggtplymdrqgidilysgsqkalnappgtslisfsdkakkkmysrktkpfsf
yldikwlanfwgcddqprmyhhtipvislyslreslaliaeqglenswrqhreaaaylhg
rlqalglqlfvkdpalrlptvttvavpagydwrdivsyvmdhfdieimgglgpstgkvlr
igllgcnatrenvdrvtealraalqhcpkkkl

    Sequence, based on observed residues (ATOM records): (download) 
    >4cbrA (A:)
hkllvtppkallkplsipnqlllgpgpsnlpprimaagglqmighmskemyqimdeikeg
iqyvfqtrnpltlvisgsghcaleaalvnvlepgdsflvgangiwgqravdigerigarv
hpmtkdpgghytlqeveeglaqhkpvllflthgesstgvlqpldgfgelchrykclllvd
svaslggtplymdrqgidilysgsqkalnappgtslisfsdkakkkmysrktkpfsfyld
ikwlanfwgcddqprmyhhtipvislyslreslaliaeqglenswrqhreaaaylhgrlq
alglqlfvkdpalrlptvttvavpagydwrdivsyvmdhfdieimgglgpstgkvlrigl
lgcnatrenvdrvtealraalqhcp