PDB entry 4ca4

View 4ca4 on RCSB PDB site
Description: Crystal structure of FimH lectin domain with the Tyr48Ala mutation, in complex with heptyl alpha-D-mannopyrannoside
Class: cell adhesion
Keywords: cell adhesion, bacterial adhesin, type 1 fimbriae, urinary tract infection, variable immunoglobulin fold, heptyl mannose, fimh antagonist
Deposited on 2013-10-06, released 2014-10-29
The last revision prior to the SCOPe 2.05 freeze date was dated 2014-10-29, with a file datestamp of 2014-10-24.
Experiment type: XRAY
Resolution: 2.84 Å
R-factor: 0.1882
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: FimH
    Species: ESCHERICHIA COLI [TaxId:364106]
    Database cross-references and differences (RAF-indexed):
    • Uniprot A2IC68 (0-157)
      • emgineered mutation (47)
      • engineered mutation (47)
    Domains in SCOPe 2.05: d4ca4a_
  • Chain 'B':
    Compound: FimH
    Species: ESCHERICHIA COLI [TaxId:364106]
    Database cross-references and differences (RAF-indexed):
    • Uniprot A2IC68 (0-157)
      • emgineered mutation (47)
      • engineered mutation (47)
    Domains in SCOPe 2.05: d4ca4b_
  • Heterogens: KGM, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4ca4A (A:)
    facktangtaipigggsanvyvnlapvvnvgqnlvvdlstqifchndapetitdyvtlqr
    gsayggvlsnfsgtvkysgssypfpttsetprvvynsrtdkpwpvalyltpvssaggvai
    kagsliavlilrqtnnynsddfqfvwniyanndvvvpt
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4ca4B (B:)
    facktangtaipigggsanvyvnlapvvnvgqnlvvdlstqifchndapetitdyvtlqr
    gsayggvlsnfsgtvkysgssypfpttsetprvvynsrtdkpwpvalyltpvssaggvai
    kagsliavlilrqtnnynsddfqfvwniyanndvvvpt