PDB entry 4c61

View 4c61 on RCSB PDB site
Description: Inhibitors of Jak2 Kinase domain
Class: transferase
Keywords: kinase, transferase
Deposited on 2013-09-17, released 2014-01-08
The last revision prior to the SCOPe 2.05 freeze date was dated 2014-01-22, with a file datestamp of 2014-01-17.
Experiment type: XRAY
Resolution: 2.45 Å
R-factor: 0.1824
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase JAK2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60674
      • engineered mutation (108)
      • engineered mutation (110)
    Domains in SCOPe 2.05: d4c61a_
  • Chain 'B':
    Compound: Tyrosine-protein kinase JAK2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60674
      • engineered mutation (108)
      • engineered mutation (110)
    Domains in SCOPe 2.05: d4c61b_
  • Heterogens: LMM, ACT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4c61A (A:)
afedrdptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrd
fereieilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqahaeridhikll
qytsqickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepg
espifwyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmi
vfhliellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdqmag

    Sequence, based on observed residues (ATOM records): (download) 
    >4c61A (A:)
feerhlkflqqlggsvemcrydplqdntgevvavkklqhsteehlrdfereieilkslqh
dnivkykgvcynlklimeylpygslrdylqahaeridhikllqytsqickgmeylgtkry
ihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvespifwyapeslteskfsvasd
vwsfgvvlyelftyieksksppaefmrmigndkqgqmivfhliellknngrlprpdgcpd
eiymimtecwnnnvnqrpsfrdlalrvdqirdqm

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4c61B (B:)
afedrdptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrd
fereieilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqahaeridhikll
qytsqickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepg
espifwyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmi
vfhliellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdqmag

    Sequence, based on observed residues (ATOM records): (download) 
    >4c61B (B:)
qfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklhlrdfereieilkslqhd
nivkykgvclklimeylpygslrdylqahaeridhikllqytsqickgmeylgtkryihr
dlatrnilvenenrvkigdfgltkvlpqdkeyykvkepgespifwyapeslteskfsvas
dvwsfgvvlyelftyieksksppaefmrmigndkqgqmivfhliellknngrlprpdgcp
deiymimtecwnnnvnqrpsfrdlalrvdqirdqma