PDB entry 4c4h

View 4c4h on RCSB PDB site
Description: Structure-based design of orally bioavailable pyrrolopyridine inhibitors of the mitotic kinase MPS1
Class: transferase
Keywords: transferase, protein kinase, mitosis, structure-based design
Deposited on 2013-09-05, released 2013-12-04
The last revision prior to the SCOPe 2.03 freeze date was dated 2013-12-04, with a file datestamp of 2013-11-29.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.1987
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dual specificity protein kinase TTK
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P33981 (23-End)
      • expression tag (20-22)
    Domains in SCOPe 2.03: d4c4ha_
  • Heterogens: 7RO, 7PE, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4c4hA (A:)
mhhhhhhssgvdlgtenlyfqsmsvkgriysilkqigsggsskvfqvlnekkqiyaikyv
nleeadnqtldsyrneiaylnklqqhsdkiirlydyeitdqyiymvmecgnidlnswlkk
kksidpwerksywknmleavhtihqhgivhsdlkpanflivdgmlklidfgianqmqpdt
tsvvkdsqvgtvnymppeaikdmsssrengkskskispksdvwslgcilyymtygktpfq
qiinqisklhaiidpnheiefpdipekdlqdvlkcclkrdpkqrisipellahpyvqiqt
hpvnqmakgttee

    Sequence, based on observed residues (ATOM records): (download) 
    >4c4hA (A:)
qsmsvkgriysilkqigsgsskvfqvlnekkqiyaikyvnleeadnqtldsyrneiayln
klqqhsdkiirlydyeitdqyiymvmecgnidlnswlkkkksidpwerksywknmleavh
tihqhgivhsdlkpanflivdgmlklidfgiatvnymppeaikdispksdvwslgcilyy
mtygktpfqqiinqisklhaiidpnheiefpdipekdlqdvlkcclkrdpkqrisipell
ahpyvqiq