PDB entry 4c4e
View 4c4e on RCSB PDB site
Description: Structure-based design of orally bioavailable pyrrolopyridine inhibitors of the mitotic kinase MPS1
Class: transferase
Keywords: transferase, mps1, ttk, protein kinase, mitosis, structure-based design
Deposited on
2013-09-05, released
2013-12-04
The last revision prior to the SCOPe 2.05 freeze date was dated
2014-01-15, with a file datestamp of
2014-01-10.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.1882
AEROSPACI score: 0.26
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Dual specificity protein kinase TTK
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d4c4ea_ - Heterogens: 4T9, 1PE, 7PE, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4c4eA (A:)
mhhhhhhssgvdlgtenlyfqsmsvkgriysilkqigsggsskvfqvlnekkqiyaikyv
nleeadnqtldsyrneiaylnklqqhsdkiirlydyeitdqyiymvmecgnidlnswlkk
kksidpwerksywknmleavhtihqhgivhsdlkpanflivdgmlklidfgianqmqpdt
tsvvkdsqvgtvnymppeaikdmsssrengkskskispksdvwslgcilyymtygktpfq
qiinqisklhaiidpnheiefpdipekdlqdvlkcclkrdpkqrisipellahpyvqiqt
hpvnqmakgttee
Sequence, based on observed residues (ATOM records): (download)
>4c4eA (A:)
qsmsvkgriysilkqigsggsskvfqvlnekkqiyaikyvnleeadnqtldsyrneiayl
nklqqhsdkiirlydyeitdqyiymvmecgnidlnswlkkkksidpwerksywknmleav
htihqhgivhsdlkpanflivdgmlklidfgianqmqpqvgtvnymppeaikdispksdv
wslgcilyymtygktpfqqiinqisklhaiidpnheiefpdipekdlqdvlkcclkrdpk
qrisipellahpyvqiq