PDB entry 4c3i

View 4c3i on RCSB PDB site
Description: Structure of 14-subunit RNA polymerase I at 3.0 A resolution, crystal form C2-100
Class: transferase
Keywords: transferase
Deposited on 2013-08-24, released 2013-10-23
The last revision prior to the SCOPe 2.07 freeze date was dated 2015-07-01, with a file datestamp of 2015-06-26.
Experiment type: XRAY
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: DNA-directed RNA polymerase I subunit rpa190
    Species: SACCHAROMYCES CEREVISIAE [TaxId:4932]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4c3ia_
  • Chain 'B':
    Compound: DNA-directed RNA polymerase I subunit rpa135
    Species: SACCHAROMYCES CEREVISIAE [TaxId:4932]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4c3ib_
  • Chain 'C':
    Compound: DNA-directed RNA polymerases I and III subunit rpac1
    Species: SACCHAROMYCES CEREVISIAE [TaxId:4932]
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: DNA-directed RNA polymerase I subunit rpa14
    Species: SACCHAROMYCES CEREVISIAE [TaxId:4932]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P50106
      • conflict (11)
  • Chain 'E':
    Compound: DNA-directed RNA polymerases I, II, and III subunit rpabc 1
    Species: SACCHAROMYCES CEREVISIAE [TaxId:4932]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4c3ie1, d4c3ie2
  • Chain 'F':
    Compound: DNA-directed RNA polymerases I, II, and III subunit rpabc 2
    Species: SACCHAROMYCES CEREVISIAE [TaxId:4932]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4c3if_
  • Chain 'G':
    Compound: DNA-directed RNA polymerase I subunit rpa43
    Species: SACCHAROMYCES CEREVISIAE [TaxId:4932]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4c3ig1
  • Chain 'H':
    Compound: DNA-directed RNA polymerases I, II, and III subunit rpabc 3
    Species: SACCHAROMYCES CEREVISIAE [TaxId:4932]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4c3ih_
  • Chain 'I':
    Compound: DNA-directed RNA polymerase I subunit rpa12
    Species: SACCHAROMYCES CEREVISIAE [TaxId:4932]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4c3ii1, d4c3ii2
  • Chain 'J':
    Compound: DNA-directed RNA polymerases I, II, and III subunit rpabc 5
    Species: SACCHAROMYCES CEREVISIAE [TaxId:4932]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4c3ij_
  • Chain 'K':
    Compound: DNA-directed RNA polymerases I and III subunit rpac2
    Species: SACCHAROMYCES CEREVISIAE [TaxId:4932]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4c3ik_
  • Chain 'L':
    Compound: DNA-directed RNA polymerases I, II, and III subunit rpabc 4
    Species: SACCHAROMYCES CEREVISIAE [TaxId:4932]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4c3il_
  • Chain 'M':
    Compound: DNA-directed RNA polymerase I subunit RPA49
    Species: SACCHAROMYCES CEREVISIAE [TaxId:4932]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4c3im_
  • Chain 'N':
    Compound: DNA-directed RNA polymerase I subunit RPA34
    Species: SACCHAROMYCES CEREVISIAE [TaxId:4932]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4c3in_
  • Heterogens: SO4, ZN, MG, MPD

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4c3iA (A:)
    mdiskpvgseitsvdfgiltakeirnlsakqitnptvldnlghpvsgglydlalgaflrn
    lcstcgldekfcpghqghielpvpcynplffnqlyiylrasclfchhfrlksvevhryac
    klrllqyglidesykldeitlgslnssmytddeaiednedemdgegskqskdisstllne
    lkskrseyvdmaiakalsdgrttergsftatvnderkklvhefhkkllsrgkcdncgmfs
    pkfrkdgftkifetalnekqitnnrvkgfirqdmikkqkqakkldgsneasandeesfdv
    grnpttrpktgstyilstevknildtvfrkeqcvlqyvfhsrpnlsrklvkadsffmdvl
    vvpptrfrlpsklgeevhensqnqllskvlttsllirdlnddlsklqkdkvsledrrvif
    srlmnafvtiqndvnafidstkaqgrtsgkvpipgvkqalekkeglfrkhmmgkrvnyaa
    rsvispdpnietneigvppvfavkltypepvtayniaelrqavingpdkwpgatqiqned
    gslvsligmsveqrkalanqlltpssnvsthtlnkkvyrhiknrdvvlmnrqptlhkasm
    mghkvrvlpnektlrlhyantgaynadfdgdemnmhfpqnenaraealnlantdsqyltp
    tsgspvrgliqdhisagvwltskdsfftreqyqqyiygcirpedghttrskivtlpptif
    kpyplwtgkqiittvllnvtppdmpginlisknkikneywgkgslenevlfkdgallcgi
    ldksqygaskygivhslhevygpevaakvlsvlgrlftnyitataftcgmddlrltaegn
    kwrtdilktsvdtgreaaaevtnldkdtpaddpellkrlqeilrdnnksgildavtsskv
    naitsqvvskcvpdgtmkkfpcnsmqamalsgakgsnvnvsqimcllgqqalegrrvpvm
    vsgktlpsfkpyetdamaggyvkgrfysgikpqeyyfhcmagreglidtavktsrsgylq
    rcltkqlegvhvsydnsirdadgtlvqfmyggdaiditkeshmtqfefcldnyyallkky
    npsaliehldvesalkyskktlkyrkkhskephykqsvkydpvlakynpakylgsvsenf
    qdklesfldknsklfkssdgvnekkfralmqlkymrslinpgeavgiiasqsvgepstqm
    tlntfhfaghgaanvtlgiprlreivmtasaaiktpqmtlpiwndvsdeqadtfcksisk
    vllsevidkvivtettgtsntaggnaarsyvihmrffdnneyseeydvskeelqnvisnq
    fihlleaaivkeikkqkrttgpdigvavprlqtdvansssnskrleedndeeqshkktkq
    avsydepdedeietmreaekssdeegidsdkesdsdsededvdmneqinksiveannnmn
    kvqrdrqsaiishhrfitkynfddesgkwcefklelaadtekllmvniveeicrksiirq
    iphidrcvhpepengkrvlvtegvnfqamwdqeafidvdgitsndvaavlktygveaarn
    tivneinnvfsryaisvsfrhldliadmmtrqgtylafnrqgmetstssfmkmsyettcq
    fltkavldnereqldspsarivvgklnnvgtgsfdvlakvpnaa
    

    Sequence, based on observed residues (ATOM records): (download)
    >4c3iA (A:)
    mdiskpvgseitsvdfgiltakeirnlsakqitnptvldnlghpvsgglydlalgaflrn
    lcstcgldekfcpghqghielpvpcynplffnqlyiylrasclfchhfrlksvevhryac
    klrllqyglidesykldeitldisstllnelkskrseyvdmaiakalsdgrttergsfta
    tvnderkklvhefhkkllsrgkcdncgmfspkfrkdgftkifetalnekqitnnrvkgfi
    rqdmistyilstevknildtvfrkeqcvlqyvfhsrpnlsrklvkadsffmdvlvvpptr
    frlpsklgeevhensqnqllskvlttsllirdlnddlsklkvsledrrvifsrlmnafvt
    iqndvnafidstkaqgrtvpipgvkqalekkeglfrkhmmgkrvnyaarsvispdpniet
    neigvppvfavkltypepvtayniaelrqavingpdkwpgatqiqnedgslvsligmsve
    qrkalanqlltpssnvsthtlnkkvyrhiknrdvvlmnrqptlhkasmmghkvrvlpnek
    tlrlhyantgaynadfdgdemnmhfpqnenaraealnlantdsqyltptsgspvrgliqd
    hisagvwltskdsfftreqyqqyiygcirpedghttrskivtlpptifkpyplwtgkqii
    ttvllnvtppdmpginlisknkikneywgkgslenevlfkdgallcgildksqygaskyg
    ivhslhevygpevaakvlsvlgrlftnyitataftcgmddlrltaegnkwrtdilktsvd
    tgreaaaevtnldkdtpaddpellkrlqeilrdnnksgildavtsskvnaitsqvvskcv
    pdgtmkkfpcnsmqamalsgakgsnvnvsqimcllgqqalegrrvpvmvsgktlpsfkpy
    etdamaggyvkgrfysgikpqeyyfhcmagreglidtavktsrsgylqrcltkqlegvhv
    sydnsirdadgtlvqfmyggdaiditkeshmtqfefcldnyyallkkynpsaliehldve
    salkyskktlkyrkkhskephykqsvkydpvlakynpakylgsvsenfqdklesfldkns
    kgvnekkfralmqlkymrslinpgeavgiiasqsvgepstqmtlntfnvtlgiprlreiv
    mtasaaiktpqmtlpiwndvsdeqadtfcksiskvllsevidkvivtettgtarsyvihm
    rffdnneyseeydvskeelqnvisnqfihlleaaivkeikkqkrttgpdigvavprlqnm
    nkvqrdrqsaiishhrfitkynfddesgkwcefklelaadtekllmvniveeicrksiir
    qiphidrcvhpepengkrvlvtegvnfqamwdqeafidvdgitsndvaavlktygveaar
    ntivneinnvfsryaisvsfrhldliadmmtrqgtylafnrqgmetstssfmkmsyettc
    qfltkavldnereqldspsarivvgklnnvgtgsfdvlakvpna
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4c3iB (B:)
    mskvikppgqartadfrtleresrfinppkdksafpllqeavqphigsfnaltegpdggl
    lnlgvkdigekvifdgkplnsedeisnsgylgnklsvsveqvsiakpmsndgvssaverk
    vypsesrqrltsyrgklllklkwsvnngeenlfevrdcgglpvmlqsnrchlnkmspyel
    vqhkeesdeiggyfivngieklirmlivqrrnhpmaiirpsfanrgasyshygiqirsvr
    pdqtsqtnvlhylndgqvtfrfswrkneylvpvvmilkalchtsdreifdgiigndvkds
    fltdrlelllrgfkkryphlqnrtqvlqylgdkfrvvfqaspdqsdlevgqevldrivlv
    hlgkdgsqdkfrmllfmirklyslvagecspdnpdatqhqevllggflygmilkekidey
    lqniiaqvrmdinrgmainfkdkrymsrvlmrvnenigskmqyflstgnlvsqsgldlqq
    vsgytvvaekinfyrfishfrmvhrgsffaqlktttvrkllpeswgflcpvhtpdgspcg
    llnhfahkcristqqsdvsripsilyslgvapashtfaagpslccvqidgkiigwvsheq
    gkiiadtlrywkvegktpglpidleigyvppstrgqypglylfgghsrmlrpvrylpldk
    edivgpfeqvymniavtpqeiqnnvhthveftptnilsilanltpfsdfnqsprnmyqcq
    mgkqtmgtpgvalchrsdnklyrlqtgqtpivkanlyddygmdnfpngfnavvavisytg
    ydmddamiinksadergfgygtmyktekvdlalnrnrgdpitqhfgfgndewpkewlekl
    dedglpyigtyveegdpicayfddtlnktkiktyhssepayieevnligdesnkfqelqt
    vsikyrirrtpqigdkfssrhgqkgvcsrkwptidmpfsetgiqpdiiinphafpsrmti
    gmfveslagkagalhgiaqdstpwifneddtpadyfgeqlakagynyhgnepmysgatge
    elradiyvgvvyyqrlrhmvndkfqvrstgpvnsltmqpvkgrkrhggirvgemerdali
    ghgtsfllqdrllnssdytqasvcrecgsilttqqsvprigsistvccrrcsmrfedakk
    lltksedgekifiddsqiwedgqgnkfvggnetttvaipfvlkyldselsamgirlrynv
    epk
    

    Sequence, based on observed residues (ATOM records): (download)
    >4c3iB (B:)
    rtadfrtleresrfinppkdksafpllqeavqphigsfnaltegpdggllnlgvkdigek
    vifdgkplnseeisnsgylgnklsvsveqvsiakpmsndsaverkvypsesrqrltsyrg
    klllklkwsvnngeenlfevrdcgglpvmlqsnrchlnkmspyelvqhkeesdeiggyfi
    vngieklirmlivqrrnhpmaiirpsfanrgasyshygiqirsvrpdqtsqtnvlhylnd
    gqvtfrfswrkneylvpvvmilkalchtsdreifdgiigndvkdsfltdrlelllrgfkk
    ryphlqnrtqvlqylgdkfrvvfqaspdqsdlevgqevldrivlvhlgkdgsqdkfrmll
    fmirklyslvagecspdnpdatqhqevllggflygmilkekideylqniiaqvrmdinrg
    mainfkdkrymsrvlmrvnenigskmqyflstgnlvsqsgldlqqvsgytvvaekinfyr
    fishfrmvhrgsffaqlktttvrkllpeswgflcpvhtpdgspcgllnhfahkcristqq
    sdvsripsilyslgvapashtfaagpslccvqidgkiigwvsheqgkiiadtlrywkveg
    ktpglpidleigyvppstrgqypglylfgghsrmlrpvrylpldkedivgpfeqvymnia
    vtpqeiqnnvhthveftptnilsilanltpfsdfnqsprnmyqcqmgkqtmgtpgvalch
    rsdnklyrlqtgqtpivkanlyddygmdnfpngfnavvavisytgydmddamiinksade
    rgfgygtmyktekvdlaldpitqhfgfgndewpkewlekldedglpyigtyveegdpica
    yfddtlnktkiktyhssepayieevnligdesnkfqelqtvsikyrirrtpqigdkfssr
    hgqkgvcsrkwptidmpfsetgiqpdiiinphafpsrmtigmfveslagkagalhgiaqd
    stpwifneddtpadyfgeqlakagynyhgnepmysgatgeelradiyvgvvyyqrlrhmv
    ndkfqvrstgpvnsltmqpvkgrkrhggirvgemerdalighgtsfllqdrllnssdytq
    asvcrecgsilttqqsvprigsistvccrrcsmrfedakkgekifiddsqiwedgqgnkf
    vggnetttvaipfvlkyldselsamgirlrynvepk
    

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4c3iE (E:)
    mdqenernisrlwrafrtvkemvkdrgyfitqeevelpledfkakycdsmgrpqrkmmsf
    qanpteesiskfpdmgslwvefcdepsvgvktmktfvihiqeknfqtgifvyqnnitpsa
    mklvpsippatietfneaalvvnithhelvpkhirlssdekrellkryrlkesqlpriqr
    adpvalylglkrgevvkiirksetsgryasyricm
    

  • Chain 'F':
    Sequence, based on SEQRES records: (download)
    >4c3iF (F:)
    msdyeeafndgnenfedfdvehfsdeetyeekpqfkdgettdangktivtggngpedfqq
    heqirrktlkekaipkdqrattpymtkyerarilgtralqismnapvfvdlegetdplri
    amkelaekkiplvirrylpdgsfedwsveelivdl
    

    Sequence, based on observed residues (ATOM records): (download)
    >4c3iF (F:)
    pedfqqheqirrktlkekaipkdqrattpymtkyerarilgtralqismnapvfvdlege
    tdplriamkelaekkiplvirrylpdgsfedwsveelivd
    

  • Chain 'G':
    Sequence, based on SEQRES records: (download)
    >4c3iG (G:)
    msqvkranenretarfikkhkkqvtnpidekngtsncivrvpialyvslapmylenplqg
    vmkqhlnplvmkynnkvggvvlgyeglkildadplskedtseklikitpdtpfgftwchv
    nlyvwqpqvgdvlegyifiqsashigllihdafnasikknnipvdwtfvhndveedadvi
    ntdenngnnnnednkdsnggsnslgkfsfgnrslghwvdsngepidgklrftvrnvhttg
    rvvsvdgtlisdadeegngynssrsqaeslpivsnkkivfddevsienkeshkeldlpev
    kedngseivyeentsesndgessdsd
    

    Sequence, based on observed residues (ATOM records): (download)
    >4c3iG (G:)
    nenretarfikkhkkqvtnpidekngtsncivrvpialyvslapmylenplqgvmkqhln
    plvmkynnkvggvvlgyeglkildadpldtseklikitpdtpfgftwchvnlyvwqpqvg
    dvlegyifiqsashigllihdafnasikknnipvdwtfvhndvelghwvdsngepidgkl
    rftvrnvhttgrvvsvdgtlisynssrsqaeslpivsnkkivfddevsienkeshkeldl
    pevkedngseivyeentse
    

  • Chain 'H':
    Sequence, based on SEQRES records: (download)
    >4c3iH (H:)
    msntlfddifqvsevdpgrynkvcrieaasttqdqckltldinvelfpvaaqdsltvtia
    sslnledtpandssatrswrppqagdrsladdydyvmygtaykfeevskdliavyysfgg
    llmrlegnyrnlnnlkqenayllirr
    

    Sequence, based on observed residues (ATOM records): (download)
    >4c3iH (H:)
    ntlfddifqvsevdpgrynkvcrieaasttqdqckltldinvelfpvaaqdsltvtiass
    lnatrswrppqagdrsladdydyvmygtaykfeevskdliavyysfggllmrlegnyrnl
    nnlkqenayllirr
    

  • Chain 'I':
    Sequence, based on SEQRES records: (download)
    >4c3iI (I:)
    msvvgslifcldcgdllenpnavlgsnvecsqckaiypksqfsnlkvvtttaddafpssl
    rakksvvktslkknelkdgatikekcpqcgneemnyhtlqlrsadegatvfytctscgyk
    frtnn
    

    Sequence, based on observed residues (ATOM records): (download)
    >4c3iI (I:)
    svvgslifcldcgdllenpnavlgsnvecsqckaiypksqfsnlkvvtttaddafpsslr
    akksvvktslkknelkdgatikekcpqcgneemnyhtlqlrsadegatvfytctscgykf
    rtnn
    

  • Chain 'J':
    Sequence, based on SEQRES records: (download)
    >4c3iJ (J:)
    mivpvrcfscgkvvgdkwesylnllqedeldegtalsrlglkryccrrmilthvdliekf
    lrynplekrd
    

    Sequence, based on observed residues (ATOM records): (download)
    >4c3iJ (J:)
    mivpvrcfscgkvvgdkwesylnllqedeldegtalsrlglkryccrrmilthvdliekf
    lrynplekr
    

  • Chain 'K':
    Sequence, based on SEQRES records: (download)
    >4c3iK (K:)
    mtedieqkktatevtpqepkhiqeeeeqdvdmtgdeeqeeepdrekiklltqatsedgts
    asfqiveedhtlgnalryvimknpdvefcgysiphpsenllniriqtygettavdalqkg
    lkdlmdlcdvveskftekiksm
    

    Sequence, based on observed residues (ATOM records): (download)
    >4c3iK (K:)
    eepdrekiklltqatsedgtsasfqiveedhtlgnalryvimknpdvefcgysiphpsen
    llniriqtygettavdalqkglkdlmdlcdvveskftekiksm
    

  • Chain 'L':
    Sequence, based on SEQRES records: (download)
    >4c3iL (L:)
    msregfqiptnldaaaagtsqartatlkyicaecssklslsrtdavrckdcghrillkar
    tkrlvqfear
    

    Sequence, based on observed residues (ATOM records): (download)
    >4c3iL (L:)
    tlkyicaecssklslsrtdavrckdcghrillkartkrlvqfear
    

  • Chain 'M':
    Sequence, based on SEQRES records: (download)
    >4c3iM (M:)
    msvkrsvseieiesvqdqpsvavgsffkgfrapsdttfdlykkkksekdefvlhgenerl
    eyegytdsssqasnqyvvglfnpekksiqlykapvlvskvvskssknlrgpkiksksdtr
    psalrnalgeafgtkkakkaiadlernridsdkltdsaidivdsvrtaskdlptraqlde
    itsndrptplanidatdveqiypiesiipkkelqfirvssilkeadkekklelfpyqnns
    kyvakkldsltqpsqmtklqllyylslllgvyenrrvnnktkllerlnsppeilvdgils
    rftvikpgqfgrskdrsyfidpqnedkilcyilaiimhldnfiveitplahelnlkpskv
    vslfrvlgaivkgatvaqaeafgipkstaasykiatmkvpfklpemtrrgrgprr
    

    Sequence, based on observed residues (ATOM records): (download)
    >4c3iM (M:)
    seieiesvqdqpsvavgsffkgfrapsdttfdlykkkekdefvlhgenerleyegytdss
    sqasnqyvvglfnpekksiqlykapvlvskvvskssknlrgpkik
    

  • Chain 'N':
    Sequence, based on SEQRES records: (download)
    >4c3iN (N:)
    msklskdyvsdsdsddevisnefsipdgfkkckhlknfplngdnkkkakqqqvwlikfps
    nvdisklkslpvdfessttmtidkhdykimddtdiessltqdnlsnmtllvpseskeslk
    iastakdnaplqfdkvfsvsetakipaidyskvrvprkdvpkveglklehfatgydaedf
    hvaeevkenkkepkkrshhddeeessekkkkkkekrekrekkdkkdkkkkhrd
    

    Sequence, based on observed residues (ATOM records): (download)
    >4c3iN (N:)
    fsipdgfkkckhlknfplngdnkqqqvwlikfpsnvdisklkslpvdfessttmtidkhd
    ykimddtdnmtllvpseskeslkiastaplqfdkvfsvsetakipaidyskvrvprkdvp
    kveglklehfatgydaedf