PDB entry 4c2p

View 4c2p on RCSB PDB site
Description: Crystal structure of human testis angiotensin-I converting enzyme mutant R522K in complex with captopril
Class: hydrolase
Keywords: hydrolase, chloride activation, hypertension
Deposited on 2013-08-19, released 2013-12-11
The last revision prior to the SCOPe 2.03 freeze date was dated 2013-12-11, with a file datestamp of 2013-12-06.
Experiment type: XRAY
Resolution: 1.99 Å
R-factor: 0.21303
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: angiotensin-converting enzyme
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P12821 (Start-588)
      • engineered mutation (485)
    Domains in SCOPe 2.03: d4c2pa_
  • Heterogens: ZN, CL, X8Z, ACT, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4c2pA (A:)
lvtdeaeaskfveeydrtsqvvwneyaeanwnyntnittetskillqknmqianhtlkyg
tqarkfdvnqlqnttikriikkvqdleraalpaqeleeynkilldmettysvatvchpng
sclqlepdltnvmatsrkyedllwawegwrdkagrailqfypkyvelinqaarlngyvda
gdswrsmyetpsleqdlerlfqelqplylnlhayvrralhrhygaqhinlegpipahllg
nmwaqtwsniydlvvpfpsapsmdtteamlkqgwtprrmfkeaddfftslgllpvppefw
nksmlekptdgrevvchasawdfyngkdfrikqcttvnledlvvahhemghiqyfmqykd
lpvalreganpgfheaigdvlalsvstpkhlhslnllsseggsdehdinflmkmaldkia
fipfsylvdqwrwrvfdgsitkenynqewwslrlkyqglcppvprtqgdfdpgakfhips
svpyikyfvsfiiqfqfhealcqaaghtgplhkcdiyqskeagqrlatamklgfsrpwpe
amqlitgqpnmsasamlsyfkplldwlrtenelhgeklgwpqynwtpns

    Sequence, based on observed residues (ATOM records): (download) 
    >4c2pA (A:)
deaeaskfveeydrtsqvvwneyaeanwnyntnittetskillqknmqianhtlkygtqa
rkfdvnqlqnttikriikkvqdleraalpaqeleeynkilldmettysvatvchpngscl
qlepdltnvmatsrkyedllwawegwrdkagrailqfypkyvelinqaarlngyvdagds
wrsmyetpsleqdlerlfqelqplylnlhayvrralhrhygaqhinlegpipahllgnmw
aqtwsniydlvvpfpsapsmdtteamlkqgwtprrmfkeaddfftslgllpvppefwnks
mlekptdgrevvchasawdfyngkdfrikqcttvnledlvvahhemghiqyfmqykdlpv
alreganpgfheaigdvlalsvstpkhlhslnllssdehdinflmkmaldkiafipfsyl
vdqwrwrvfdgsitkenynqewwslrlkyqglcppvprtqgdfdpgakfhipssvpyiky
fvsfiiqfqfhealcqaaghtgplhkcdiyqskeagqrlatamklgfsrpwpeamqlitg
qpnmsasamlsyfkplldwlrtenelhgeklgwpqynwtpns