PDB entry 4c2m

View 4c2m on RCSB PDB site
Description: Structure of RNA polymerase I at 2.8 A resolution
Class: transcription
Keywords: transcription, ribosome biogenesis
Deposited on 2013-08-19, released 2013-10-23
The last revision prior to the SCOPe 2.05 freeze date was dated 2013-11-06, with a file datestamp of 2013-11-01.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.1697
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

• Chain '1':
  Compound: DNA-directed RNA polymerases I, II, and III subunit rpabc 4
  Species: Saccharomyces cerevisiae [TaxId:4932]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P40422 (Start-69)
  Domains in SCOPe 2.05: d4c2m1_
• Chain '2':
  Compound: DNA-directed RNA polymerase I subunit RPA49
  Species: Saccharomyces cerevisiae [TaxId:4932]
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q01080
• Chain '3':
  Compound: DNA-directed RNA polymerase I subunit RPA34
  Species: Saccharomyces cerevisiae [TaxId:4932]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P47006
• Chain '4':
  Compound: DNA-directed RNA polymerase I subunit rpa43
  Species: Saccharomyces cerevisiae [TaxId:4932]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P46669
• Chain 'A':
  Compound: DNA-directed RNA polymerase I subunit rpa190
  Species: Saccharomyces cerevisiae [TaxId:4932]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P10964 (0-1663)
• Chain 'B':
  Compound: DNA-directed RNA polymerase I subunit rpa135
  Species: Saccharomyces cerevisiae [TaxId:4932]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P22138 (Start-1202)
• Chain 'C':
  Compound: DNA-directed RNA polymerases I and III subunit rpac1
  Species: Saccharomyces cerevisiae [TaxId:4932]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P07703 (Start-334)
• Chain 'D':
  Compound: DNA-directed RNA polymerase I subunit rpa14
  Species: Saccharomyces cerevisiae [TaxId:4932]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P50106
• Chain 'E':
  Compound: DNA-directed RNA polymerases I, II, and III subunit rpabc 1
  Species: Saccharomyces cerevisiae [TaxId:4932]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P20434 (Start-214)
  Domains in SCOPe 2.05: d4c2me1, d4c2me2
• Chain 'F':
  Compound: DNA-directed RNA polymerases I, II, and III subunit rpabc 2
  Species: Saccharomyces cerevisiae [TaxId:4932]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P20435
  Domains in SCOPe 2.05: d4c2mf_
• Chain 'G':
  Compound: DNA-directed RNA polymerase I subunit rpa43
  Species: Saccharomyces cerevisiae [TaxId:4932]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P46669
• Chain 'H':
  Compound: DNA-directed RNA polymerases I, II, and III subunit rpabc 3
  Species: Saccharomyces cerevisiae [TaxId:4932]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P20436 (Start-145)
  Domains in SCOPe 2.05: d4c2mh_
• Chain 'I':
  Compound: DNA-directed RNA polymerase I subunit rpa12
  Species: Saccharomyces cerevisiae [TaxId:4932]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P32529 (Start-124)
• Chain 'J':
  Compound: DNA-directed RNA polymerases I, II, and III subunit rpabc 5
  Species: Saccharomyces cerevisiae [TaxId:4932]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P22139 (0-End)
  Domains in SCOPe 2.05: d4c2mj_
• Chain 'K':
  Compound: DNA-directed RNA polymerases I and III subunit rpac2
  Species: Saccharomyces cerevisiae [TaxId:4932]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P28000 (Start-141)
  Domains in SCOPe 2.05: d4c2mk_
• Chain 'L':
  Compound: DNA-directed RNA polymerases I, II, and III subunit rpabc 4
  Species: Saccharomyces cerevisiae [TaxId:4932]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P40422 (Start-69)
  Domains in SCOPe 2.05: d4c2ml_
• Chain 'M':
  Compound: DNA-directed RNA polymerase I subunit RPA49
  Species: Saccharomyces cerevisiae [TaxId:4932]
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q01080
• Chain 'N':
  Compound: DNA-directed RNA polymerase I subunit RPA34
  Species: Saccharomyces cerevisiae [TaxId:4932]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P47006
• Chain 'O':
  Compound: DNA-directed RNA polymerase I subunit rpa43
  Species: Saccharomyces cerevisiae [TaxId:4932]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P46669
• Chain 'P':
  Compound: DNA-directed RNA polymerase I subunit rpa190
  Species: Saccharomyces cerevisiae [TaxId:4932]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P10964 (0-1663)
• Chain 'Q':
  Compound: DNA-directed RNA polymerase I subunit rpa135
  Species: Saccharomyces cerevisiae [TaxId:4932]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P22138 (Start-1202)
• Chain 'R':
  Compound: DNA-directed RNA polymerases I and III subunit rpac1
  Species: Saccharomyces cerevisiae [TaxId:4932]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P07703 (Start-334)
• Chain 'S':
  Compound: DNA-directed RNA polymerase I subunit rpa14
  Species: Saccharomyces cerevisiae [TaxId:4932]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P50106
• Chain 'T':
  Compound: DNA-directed RNA polymerases I, II, and III subunit rpabc 1
  Species: Saccharomyces cerevisiae [TaxId:4932]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P20434 (Start-214)
  Domains in SCOPe 2.05: d4c2mt1, d4c2mt2
• Chain 'U':
  Compound: DNA-directed RNA polymerases I, II, and III subunit rpabc 2
  Species: Saccharomyces cerevisiae [TaxId:4932]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P20435
  Domains in SCOPe 2.05: d4c2mu_
• Chain 'V':
  Compound: DNA-directed RNA polymerase I subunit rpa43
  Species: Saccharomyces cerevisiae [TaxId:4932]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P46669
• Chain 'W':
  Compound: DNA-directed RNA polymerases I, II, and III subunit rpabc 3
  Species: Saccharomyces cerevisiae [TaxId:4932]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P20436 (Start-145)
  Domains in SCOPe 2.05: d4c2mw_
• Chain 'X':
  Compound: DNA-directed RNA polymerase I subunit rpa12
  Species: Saccharomyces cerevisiae [TaxId:4932]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P32529 (Start-124)
• Chain 'Y':
  Compound: DNA-directed RNA polymerases I, II, and III subunit rpabc 5
  Species: Saccharomyces cerevisiae [TaxId:4932]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P22139 (0-End)
  Domains in SCOPe 2.05: d4c2my_
• Chain 'Z':
  Compound: DNA-directed RNA polymerases I and III subunit rpac2
  Species: Saccharomyces cerevisiae [TaxId:4932]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P28000 (Start-141)
  Domains in SCOPe 2.05: d4c2mz_
• Heterogens: ZN, SO4, HOH

PDB Chain Sequences:

• Chain '1':
  Sequence, based on SEQRES records: (download)
  

  >4c2m1 (1:)
  msregfqiptnldaaaagtsqartatlkyicaecssklslsrtdavrckdcghrillkar
  tkrlvqfear
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >4c2m1 (1:)
  lkyicaecssklslsrtdavrckdcghrillkartkrlvqfear
  

  
  
• Chain '2':
  No sequence available.
  
  
• Chain '3':
  No sequence available.
  
  
• Chain '4':
  No sequence available.
  
  
• Chain 'A':
  No sequence available.
  
  
• Chain 'B':
  No sequence available.
  
  
• Chain 'C':
  No sequence available.
  
  
• Chain 'D':
  No sequence available.
  
  
• Chain 'E':
  Sequence, based on SEQRES records: (download)
  

  >4c2mE (E:)
  mdqenernisrlwrafrtvkemvkdrgyfitqeevelpledfkakycdsmgrpqrkmmsf
  qanpteesiskfpdmgslwvefcdepsvgvktmktfvihiqeknfqtgifvyqnnitpsa
  mklvpsippatietfneaalvvnithhelvpkhirlssdekrellkryrlkesqlpriqr
  adpvalylglkrgevvkiirksetsgryasyricm
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >4c2mE (E:)
  enernisrlwrafrtvkemvkdrgyfitqeevelpledfkakycdsmgrpqrkmmsfqan
  pteesiskfpdmgslwvefcdepsvgvktmktfvihiqeknfqtgifvyqnnitpsamkl
  vpsippatietfneaalvvnithhelvpkhirlssdekrellkryrlkesqlpriqradp
  valylglkrgevvkiirksetsgryasyricm
  

  
  
• Chain 'F':
  Sequence, based on SEQRES records: (download)
  

  >4c2mF (F:)
  msdyeeafndgnenfedfdvehfsdeetyeekpqfkdgettdangktivtggngpedfqq
  heqirrktlkekaipkdqrattpymtkyerarilgtralqismnapvfvdlegetdplri
  amkelaekkiplvirrylpdgsfedwsveelivdl
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >4c2mF (F:)
  pedfqqheqirrktlkekaipkdqrattpymtkyerarilgtralqismnapvfvdlege
  tdplriamkelaekkiplvirrylpdgsfedwsveelivd
  

  
  
• Chain 'G':
  No sequence available.
  
  
• Chain 'H':
  Sequence, based on SEQRES records: (download)
  

  >4c2mH (H:)
  msntlfddifqvsevdpgrynkvcrieaasttqdqckltldinvelfpvaaqdsltvtia
  sslnledtpandssatrswrppqagdrsladdydyvmygtaykfeevskdliavyysfgg
  llmrlegnyrnlnnlkqenayllirr
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >4c2mH (H:)
  ntlfddifqvsevdpgrynkvcrieaasttqdqckltldinvelfpvaaqdsltvtiass
  lnswrppqagdrsladdydyvmygtaykfeevskdliavyysfggllmrlegnyrnlnnl
  kqenayllirr
  

  
  
• Chain 'I':
  No sequence available.
  
  
• Chain 'J':
  Sequence, based on SEQRES records: (download)
  

  >4c2mJ (J:)
  mivpvrcfscgkvvgdkwesylnllqedeldegtalsrlglkryccrrmilthvdliekf
  lrynplekrd
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >4c2mJ (J:)
  mivpvrcfscgkvvgdkwesylnllqedeldegtalsrlglkryccrrmilthvdliekf
  lrynplekr
  

  
  
• Chain 'K':
  Sequence, based on SEQRES records: (download)
  

  >4c2mK (K:)
  mtedieqkktatevtpqepkhiqeeeeqdvdmtgdeeqeeepdrekiklltqatsedgts
  asfqiveedhtlgnalryvimknpdvefcgysiphpsenllniriqtygettavdalqkg
  lkdlmdlcdvveskftekiksm
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >4c2mK (K:)
  pdrekiklltqatsedgtsasfqiveedhtlgnalryvimknpdvefcgysiphpsenll
  niriqtygettavdalqkglkdlmdlcdvveskftekiksm
  

  
  
• Chain 'L':
  Sequence, based on SEQRES records: (download)
  

  >4c2mL (L:)
  msregfqiptnldaaaagtsqartatlkyicaecssklslsrtdavrckdcghrillkar
  tkrlvqfear
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >4c2mL (L:)
  lkyicaecssklslsrtdavrckdcghrillkartkrlvqfear
  

  
  
• Chain 'M':
  No sequence available.
  
  
• Chain 'N':
  No sequence available.
  
  
• Chain 'O':
  No sequence available.
  
  
• Chain 'P':
  No sequence available.
  
  
• Chain 'Q':
  No sequence available.
  
  
• Chain 'R':
  No sequence available.
  
  
• Chain 'S':
  No sequence available.
  
  
• Chain 'T':
  Sequence, based on SEQRES records: (download)
  

  >4c2mT (T:)
  mdqenernisrlwrafrtvkemvkdrgyfitqeevelpledfkakycdsmgrpqrkmmsf
  qanpteesiskfpdmgslwvefcdepsvgvktmktfvihiqeknfqtgifvyqnnitpsa
  mklvpsippatietfneaalvvnithhelvpkhirlssdekrellkryrlkesqlpriqr
  adpvalylglkrgevvkiirksetsgryasyricm
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >4c2mT (T:)
  enernisrlwrafrtvkemvkdrgyfitqeevelpledfkakycdsmgrpqrkmmsfqan
  pteesiskfpdmgslwvefcdepsvgvktmktfvihiqeknfqtgifvyqnnitpsamkl
  vpsippatietfneaalvvnithhelvpkhirlssdekrellkryrlkesqlpriqradp
  valylglkrgevvkiirksetsgryasyricm
  

  
  
• Chain 'U':
  Sequence, based on SEQRES records: (download)
  

  >4c2mU (U:)
  msdyeeafndgnenfedfdvehfsdeetyeekpqfkdgettdangktivtggngpedfqq
  heqirrktlkekaipkdqrattpymtkyerarilgtralqismnapvfvdlegetdplri
  amkelaekkiplvirrylpdgsfedwsveelivdl
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >4c2mU (U:)
  pedfqqheqirrktlkekaipkdqrattpymtkyerarilgtralqismnapvfvdlege
  tdplriamkelaekkiplvirrylpdgsfedwsveelivd
  

  
  
• Chain 'V':
  No sequence available.
  
  
• Chain 'W':
  Sequence, based on SEQRES records: (download)
  

  >4c2mW (W:)
  msntlfddifqvsevdpgrynkvcrieaasttqdqckltldinvelfpvaaqdsltvtia
  sslnledtpandssatrswrppqagdrsladdydyvmygtaykfeevskdliavyysfgg
  llmrlegnyrnlnnlkqenayllirr
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >4c2mW (W:)
  ntlfddifqvsevdpgrynkvcrieaasttqdqckltldinvelfpvaaqdsltvtiass
  lnswrppqagdrsladdydyvmygtaykfeevskdliavyysfggllmrlegnyrnlnnl
  kqenayllirr
  

  
  
• Chain 'X':
  No sequence available.
  
  
• Chain 'Y':
  Sequence, based on SEQRES records: (download)
  

  >4c2mY (Y:)
  mivpvrcfscgkvvgdkwesylnllqedeldegtalsrlglkryccrrmilthvdliekf
  lrynplekrd
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >4c2mY (Y:)
  mivpvrcfscgkvvgdkwesylnllqedeldegtalsrlglkryccrrmilthvdliekf
  lrynplekr
  

  
  
• Chain 'Z':
  Sequence, based on SEQRES records: (download)
  

  >4c2mZ (Z:)
  mtedieqkktatevtpqepkhiqeeeeqdvdmtgdeeqeeepdrekiklltqatsedgts
  asfqiveedhtlgnalryvimknpdvefcgysiphpsenllniriqtygettavdalqkg
  lkdlmdlcdvveskftekiksm
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >4c2mZ (Z:)
  drekiklltqatsedgtsasfqiveedhtlgnalryvimknpdvefcgysiphpsenlln
  iriqtygettavdalqkglkdlmdlcdvveskftekiksm