PDB entry 4bzn

View 4bzn on RCSB PDB site
Description: Crystal structure of PIM1 in complex with a Pyrrolo(1,2-a)Pyrazinone inhibitor
Class: transferase
Keywords: pim1, ATP binding, kinase inhibitor, transferase
Deposited on 2013-07-29, released 2013-10-30
The last revision prior to the SCOPe 2.05 freeze date was dated 2013-11-13, with a file datestamp of 2013-11-08.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.17766
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein kinase pim-1
    Species: Homo sapiens [TaxId:9606]
    Gene:
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4bzna_
  • Heterogens: UGX, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4bznA (A:)
    gpllskinslahlraapcndlhatklapgkekeplesqyqvgpllgsggfgsvysgirvs
    dnlpvaikhvekdrisdwgelpngtrvpmevvllkkvssgfsgvirlldwferpdsfvli
    lerpepvqdlfdfitergalqeelarsffwqvleavrhchncgvlhrdikdenilidlnr
    gelklidfgsgallkdtvytdfdgtrvysppewiryhryhgrsaavwslgillydmvcgd
    ipfehdeeiirgqvffrqrvssecqhlirwclalrpsdrptfeeiqnhpwmqdvllpqet
    aeihlhslspgpsk
    

    Sequence, based on observed residues (ATOM records): (download)
    >4bznA (A:)
    plesqyqvgpllgsggfgsvysgirvsdnlpvaikhvekdrisdwgelpngtrvpmevvl
    lkkvssgfsgvirlldwferpdsfvlilerpepvqdlfdfitergalqeelarsffwqvl
    eavrhchncgvlhrdikdenilidlnrgelklidfgsgallkdtvytdfdgtrvysppew
    iryhryhgrsaavwslgillydmvcgdipfehdeeiirgqvffrqrvssecqhlirwcla
    lrpsdrptfeeiqnhpwmqdvllpqetaeihlh