PDB entry 4bsw

View 4bsw on RCSB PDB site
Description: Heterodimeric Fc Antibody Azymetric Variant 2
Class: immune system
Keywords: immune system, bispecific, scaffold, antibody engineering, fc domain, igg, igg1, immunoglobulin g, zymeworks inc.
Deposited on 2013-06-11, released 2013-08-21
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-06-29.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: heterodimeric fc antibody azymetric variant 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01857
      • engineered mutation (128)
      • microheterogeneity (129)
      • microheterogeneity (144)
      • microheterogeneity (170)
      • microheterogeneity (172)
      • microheterogeneity (183)
      • microheterogeneity (185)
    Domains in SCOPe 2.08: d4bswa1, d4bswa2
  • Chain 'B':
    Compound: heterodimeric fc antibody azymetric variant 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01857
      • engineered mutation (128)
      • microheterogeneity (129)
      • microheterogeneity (144)
      • microheterogeneity (170)
      • microheterogeneity (172)
      • microheterogeneity (183)
      • microheterogeneity (185)
    Domains in SCOPe 2.08: d4bswb1, d4bswb2
  • Heterogens: EDO, IOD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4bswA (A:)
gthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdg
vevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakg
qprepqvyvyppsrdeltknqvsltclvkgfypsdiavewesngqpennykttppvldsd
gsfalvskltvdksrwqqgnvfscsvmhealhnhytqkslslspgk

    Sequence, based on observed residues (ATOM records): (download) 
    >4bswA (A:)
ggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeq
ynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqprepqvyvyppsr
deltknqvsltclvkgfypsdiavewesngqpennykttppvldsdgsfalvskltvdks
rwqqgnvfscsvmhealhnhytqkslslsp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4bswB (B:)
gthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdg
vevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakg
qprepqvyvlppsrdeltknqvsllclvkgfypsdiavewesngqpennyltwppvldsd
gsfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslspgk

    Sequence, based on observed residues (ATOM records): (download) 
    >4bswB (B:)
ggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeq
ynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqprepqvyvlppsr
deltknqvsllclvkgfypsdiavewesngqpennyltwppvldsdgsfflyskltvdks
rwqqgnvfscsvmhealhnhytqkslslsp