PDB entry 4bco

View 4bco on RCSB PDB site
Description: Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor
Class: transferase/cell cycle
Keywords: transferase-cell cycle complex, cdk-cyclin complex, cyclin-inhibitor, structure-based drug design
Deposited on 2012-10-02, released 2013-01-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2013-02-27, with a file datestamp of 2013-02-22.
Experiment type: XRAY
Resolution: 2.05 Å
R-factor: 0.1906
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cyclin-dependent kinase 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P24941 (2-299)
      • expression tag (1)
    Domains in SCOPe 2.08: d4bcoa1, d4bcoa2
  • Chain 'B':
    Compound: Cyclin-A2
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4bcob1, d4bcob2
  • Chain 'C':
    Compound: cyclin-dependent kinase 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P24941 (2-End)
      • expression tag (1)
    Domains in SCOPe 2.08: d4bcoc1, d4bcoc2
  • Chain 'D':
    Compound: Cyclin-A2
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4bcod1, d4bcod2
  • Heterogens: T6Q, SGM, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4bcoA (A:)
gsmenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkel
nhpnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafc
hshrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgck
yystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykp
sfpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl

    Sequence, based on observed residues (ATOM records): (download) 
    >4bcoA (A:)
smenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkeln
hpnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafch
shrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgcky
ystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykps
fpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4bcoB (B:)
svnevpdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqne
tlhlavnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkq
vlrmehlvlkvltfdlaaptvnqfltqyflhqqpanckveslamflgelslidadpylky
lpsviaaaafhlalytvtgqswpeslirktgytleslkpclmdlhqtylkapqhaqqsir
ekyknskyhgvsllnppetlnl

    Sequence, based on observed residues (ATOM records): (download) 
    >4bcoB (B:)
vpdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnetlhl
avnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkqvlrm
ehlvlkvltfdlaaptvnqfltqyflhqqpanckveslamflgelslidadpylkylpsv
iaaaafhlalytvtgqswpeslirktgytleslkpclmdlhqtylkapqhaqqsirekyk
nskyhgvsllnppetlnl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4bcoC (C:)
gsmenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkel
nhpnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafc
hshrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgck
yystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykp
sfpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl

    Sequence, based on observed residues (ATOM records): (download) 
    >4bcoC (C:)
smenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkeln
hpnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafch
shrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgcky
ystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtskvvppldedgrsllsqm
lhydpnkrisakaalahpffqdvtkpvphl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4bcoD (D:)
svnevpdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqne
tlhlavnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkq
vlrmehlvlkvltfdlaaptvnqfltqyflhqqpanckveslamflgelslidadpylky
lpsviaaaafhlalytvtgqswpeslirktgytleslkpclmdlhqtylkapqhaqqsir
ekyknskyhgvsllnppetlnl

    Sequence, based on observed residues (ATOM records): (download) 
    >4bcoD (D:)
dyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnetlhlav
nyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkqvlrmeh
lvlkvltfdlaaptvnqfltqyflhqqpanckveslamflgelslidadpylkylpsvia
aaafhlalytvtgqswpeslirktgytleslkpclmdlhqtylkapqhaqqsirekykns
kyhgvsllnppetlnl