PDB entry 4bcn

View 4bcn on RCSB PDB site
Description: Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor
Class: transferase/cell cycle
Keywords: transferase-cell cycle complex, cdk-cyclin complex, cyclin-inhibitor, structure-based drug design
Deposited on 2012-10-02, released 2013-03-06
The last revision prior to the SCOPe 2.05 freeze date was dated 2013-03-06, with a file datestamp of 2013-03-01.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.1856
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cyclin-dependent kinase 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P24941 (2-299)
      • expression tag (1)
    Domains in SCOPe 2.05: d4bcna_
  • Chain 'B':
    Compound: Cyclin-A2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P20248 (Start-261)
      • conflict (186)
      • conflict (221)
      • conflict (229)
      • conflict (232)
    Domains in SCOPe 2.05: d4bcnb1, d4bcnb2
  • Chain 'C':
    Compound: cyclin-dependent kinase 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P24941 (2-End)
      • expression tag (0-1)
    Domains in SCOPe 2.05: d4bcnc_
  • Chain 'D':
    Compound: Cyclin-A2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P20248 (Start-260)
      • conflict (186)
      • conflict (221)
    Domains in SCOPe 2.05: d4bcnd1, d4bcnd2
  • Heterogens: T9N, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4bcnA (A:)
gsmenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkel
nhpnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafc
hshrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgck
yystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykp
sfpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl

    Sequence, based on observed residues (ATOM records): (download) 
    >4bcnA (A:)
smenfqkvekigegtygvvykarnkltgevvalkkirldtegvpstaireisllkelnhp
nivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchsh
rvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyys
tavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfp
kwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4bcnB (B:)
svnevpdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqne
tlhlavnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkq
vlrmehlvlkvltfdlaaptvnqfltqyflhqqpanckveslamflgelslidadpylky
lpsviaaaafhlalytvtgqswpeslirktgytleslkpclldlhqtylrapkhaqqsir
ekyknskyhgvsllnppetlnl

    Sequence, based on observed residues (ATOM records): (download) 
    >4bcnB (B:)
pdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnetlhla
vnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkqvlrme
hlvlkvltfdlaaptvnqfltqyflhqqpanckveslamflgelslidadpylkylpsvi
aaaafhlalytvtgqswpeslirktgytleslkpclldlhqtylrapkhaqqsirekykn
skyhgvsllnppetlnl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4bcnC (C:)
gsmenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkel
nhpnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafc
hshrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgck
yystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykp
sfpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl

    Sequence, based on observed residues (ATOM records): (download) 
    >4bcnC (C:)
gsmenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkel
nhpnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafc
hshrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgck
yystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykp
sfpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvp

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4bcnD (D:)
svnevpdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqne
tlhlavnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkq
vlrmehlvlkvltfdlaaptvnqfltqyflhqqpanckveslamflgelslidadpylky
lpsviaaaafhlalytvtgqswpeslirktgytleslkpclldlhqtylkapqhaqqsir
ekyknskyhgvsllnppetlnv

    Sequence, based on observed residues (ATOM records): (download) 
    >4bcnD (D:)
dyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnetlhlav
nyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkqvlrmeh
lvlkvltfdlaaptvnqfltqyflhqqpanckveslamflgelslidadpylkylpsvia
aaafhlalytvtgqswpeslirktgytleslkpclldlhqtylkapqhaqqsirekykns
kyhgvsllnppetln