PDB entry 4bch
View 4bch on RCSB PDB site
Description: Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor
Class: transferase/cell cycle
Keywords: transferase-cell cycle complex, cdk-cyclin complex, transcription-protein binding, structure-based drug design
Deposited on
2012-10-02, released
2013-01-09
The last revision prior to the SCOPe 2.08 freeze date was dated
2019-05-15, with a file datestamp of
2019-05-10.
Experiment type: XRAY
Resolution: 2.96 Å
R-factor: N/A
AEROSPACI score: 0.14
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Cyclin-dependent kinase 9
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4bcha_ - Chain 'B':
Compound: Cyclin-T1
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot O60563 (Start-259)
- engineered mutation (77)
- engineered mutation (96)
- engineered mutation (241)
Domains in SCOPe 2.08: d4bchb1, d4bchb2 - Heterogens: T7Z, GOL, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4bchA (A:)
gpakqydsvecpfcdevskyeklakigqgtfgevfkarhrktgqkvalkkvlmenekegf
pitalreikilqllkhenvvnlieicrtkaspynrckgsiylvfdfcehdlagllsnvlv
kftlseikrvmqmllnglyyihrnkilhrdmkaanvlitrdgvlkladfglarafslakn
sqpnrytnrvvtlwyrppelllgerdygppidlwgagcimaemwtrspimqgnteqhqla
lisqlcgsitpevwpnvdnyelyeklelvkgqkrkvkdrlkayvrdpyaldlidkllvld
paqridsddalnhdffwsdpmpsdlkgmlst
Sequence, based on observed residues (ATOM records): (download)
>4bchA (A:)
svecpfcdevskyeklakigqgtfgevfkarhrktgqkvalkkvlmenekegfpitalre
ikilqllkhenvvnlieicrtkagsiylvfdfcehdlagllsnvlvkftlseikrvmqml
lnglyyihrnkilhrdmkaanvlitrdgvlkladfglarafslpnrytnrvvtlwyrppe
lllgerdygppidlwgagcimaemwtrspimqgnteqhqlalisqlcgsitpevwpnvdn
yelyeklelvkgqkrkvkdrlkayvrdpyaldlidkllvldpaqridsddalnhdffwsd
pmpsdlkgm
- Chain 'B':
Sequence, based on SEQRES records: (download)
>4bchB (B:)
gpegerknnnkrwyftreqlenspsrrfgvdpdkelsyrqqaanllqdmgqrlnvsqlti
ntaivymhrfymiqsftrfpgnsvapaalflaakvegqpkklehvikvahtclhpqeslp
dtrseaylqqvqdlvilesiilqtlgfeltidhphthvvkctqlvraskdlaqtsyfmat
nslhlttfslqytppvvacvcihlackwsnweipvstdgkhwweyvdatvtlelldelth
ellqilektpnrlkriwnwr
Sequence, based on observed residues (ATOM records): (download)
>4bchB (B:)
nnkrwyftreqlenspsrrfgvdpdkelsyrqqaanllqdmgqrlnvsqltintaivymh
rfymiqsftrfpgnsvapaalflaakvegqpkklehvikvahtclhpqeslpdtrseayl
qqvqdlvilesiilqtlgfeltidhphthvvkctqlvraskdlaqtsyfmatnslhlttf
slqytppvvacvcihlackwsnweipvstdgkhwweyvdatvtlelldelthellqilek
tpnrlkriwnwr