PDB entry 4bbm

View 4bbm on RCSB PDB site
Description: crystal structure of the human cdkl2 kinase domain with bound tcs 2312
Class: transferase
Keywords: transferase, phospho-mimetic
Deposited on 2012-09-26, released 2012-10-17
The last revision prior to the SCOPe 2.07 freeze date was dated 2012-10-17, with a file datestamp of 2012-10-12.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.24386
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cyclin-dependent kinase-like 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q92772 (23-330)
      • expression tag (15-22)
      • engineered mutation (181)
      • engineered mutation (183)
    Domains in SCOPe 2.07: d4bbma1, d4bbma2
  • Chain 'B':
    Compound: cyclin-dependent kinase-like 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q92772 (23-330)
      • expression tag (19-22)
      • engineered mutation (181)
      • engineered mutation (183)
    Domains in SCOPe 2.07: d4bbmb1, d4bbmb2
  • Heterogens: TC0, CL, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4bbmA (A:)
mghhhhhhssgvdlgtenlyfqsmekyenlglvgegsygmvmkcrnkdtgrivaikkfle
sdddkmvkkiamreikllkqlrhenlvnllevckkkkrwylvfefvdhtilddlelfpng
ldyqvvqkylfqiingigfchshniihrdikpenilvsqsgvvklcdfgfartlaapgev
yddevatrwyrapellvgdvkygkavdvwaigclvtemfmgeplfpgdsdidqlyhimmc
lgnliprhqelfnknpvfagvrlpeikereplerrypklsevvidlakkclhidpdkrpf
caellhhdffqmdgfaerfsqelqlkvqkda

    Sequence, based on observed residues (ATOM records): (download) 
    >4bbmA (A:)
tenlyfqsmekyenlglvgsygmvmkcrnkdtgrivaikkflesdddkmvkkiamreikl
lkqlrhenlvnllevckkkkrwylvfefvdhtilddlelfpngldyqvvqkylfqiingi
gfchshniihrdikpenilvsqsgvvklcdfgfartlaapgevyddevatrwyrapellv
gdvkygkavdvwaigclvtemfmgeplfpgdsdidqlyhimmclgnliprhqelfnknpv
fagvrlpeikereplerrypklsevvidlakkclhidpdkrpfcaellhhdffqmdgfae
rfsqelqlkvqkda

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4bbmB (B:)
mghhhhhhssgvdlgtenlyfqsmekyenlglvgegsygmvmkcrnkdtgrivaikkfle
sdddkmvkkiamreikllkqlrhenlvnllevckkkkrwylvfefvdhtilddlelfpng
ldyqvvqkylfqiingigfchshniihrdikpenilvsqsgvvklcdfgfartlaapgev
yddevatrwyrapellvgdvkygkavdvwaigclvtemfmgeplfpgdsdidqlyhimmc
lgnliprhqelfnknpvfagvrlpeikereplerrypklsevvidlakkclhidpdkrpf
caellhhdffqmdgfaerfsqelqlkvqkda

    Sequence, based on observed residues (ATOM records): (download) 
    >4bbmB (B:)
yfqsmekyenlgsygmvmkcrnkdtgrivaikkfkkiamreikllkqlrhenlvnllevc
ylvfefvdhtilddlelfpngldyqvvqkylfqiingigfchshniihrdikpenilvsq
sgvvklcdfgfartlaapgevyddevatrwyrapellvgdvkygkavdvwaigclvtemf
mgeplfpgdsdidqlyhimmclgnliprhqelfnknpvfagvrlpeikereplerrypkl
sevvidlakkclhidpdkrpfcaellhhdffqmdgfaerfsqelqlkvqkda