PDB entry 4b7r

View 4b7r on RCSB PDB site
Description: H1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant Explained by Kinetic and Structural Analysis
Class: hydrolase
Keywords: hydrolase, neuraminidase inhibitor, nai, nais, zanamivir, resistance, antiviral resistance
Deposited on 2012-08-21, released 2012-10-03
The last revision prior to the SCOPe 2.05 freeze date was dated 2013-07-17, with a file datestamp of 2013-07-12.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.1471
AEROSPACI score: 0.52 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Neuraminidase
    Species: INFLUENZA A VIRUS (A/CALIFORNIA/07/2009(H1N1)) [TaxId:641809]
    Gene:
    Database cross-references and differences (RAF-indexed):
    • Uniprot C7FH46 (0-386)
      • variant (268)
    Domains in SCOPe 2.05: d4b7ra_
  • Chain 'B':
    Compound: Neuraminidase
    Species: INFLUENZA A VIRUS (A/CALIFORNIA/07/2009(H1N1)) [TaxId:641809]
    Gene:
    Database cross-references and differences (RAF-indexed):
    • Uniprot C7FH46 (0-386)
      • variant (268)
    Domains in SCOPe 2.05: d4b7rb_
  • Chain 'C':
    Compound: Neuraminidase
    Species: INFLUENZA A VIRUS (A/CALIFORNIA/07/2009(H1N1)) [TaxId:641809]
    Gene:
    Database cross-references and differences (RAF-indexed):
    • Uniprot C7FH46 (0-386)
      • variant (268)
    Domains in SCOPe 2.05: d4b7rc_
  • Chain 'D':
    Compound: Neuraminidase
    Species: INFLUENZA A VIRUS (A/CALIFORNIA/07/2009(H1N1)) [TaxId:641809]
    Gene:
    Database cross-references and differences (RAF-indexed):
    • Uniprot C7FH46 (0-386)
      • variant (268)
    Domains in SCOPe 2.05: d4b7rd_
  • Heterogens: CA, G39, EPE, NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4b7rA (A:)
    vklagnsslcpvsgwaiyskdnsvrigskgdvfvirepfiscsplecrtffltqgallnd
    khsngtikdrspyrtlmscpigevpspynsrfesvawsasachdginwltigisgpdnga
    vavlkyngiitdtikswrnnilrtqesecacvngscftvmtdgpsngqasykifriekgk
    ivksvemnapnyhyeecscypdsseitcvcrdnwhgsnrpwvsfnqnleyqigyicsgif
    gdnprpndktgscgpvssngangvkgfsfkygngvwigrtksissrngfemiwdpngwtg
    tdnnfsikqdivginewsgysgsfvqhpeltgldcirpcfwvelirgrpkentiwtsgss
    isfcgvnsdtvgwswpdgaelpftidk
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4b7rB (B:)
    vklagnsslcpvsgwaiyskdnsvrigskgdvfvirepfiscsplecrtffltqgallnd
    khsngtikdrspyrtlmscpigevpspynsrfesvawsasachdginwltigisgpdnga
    vavlkyngiitdtikswrnnilrtqesecacvngscftvmtdgpsngqasykifriekgk
    ivksvemnapnyhyeecscypdsseitcvcrdnwhgsnrpwvsfnqnleyqigyicsgif
    gdnprpndktgscgpvssngangvkgfsfkygngvwigrtksissrngfemiwdpngwtg
    tdnnfsikqdivginewsgysgsfvqhpeltgldcirpcfwvelirgrpkentiwtsgss
    isfcgvnsdtvgwswpdgaelpftidk
    

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4b7rC (C:)
    vklagnsslcpvsgwaiyskdnsvrigskgdvfvirepfiscsplecrtffltqgallnd
    khsngtikdrspyrtlmscpigevpspynsrfesvawsasachdginwltigisgpdnga
    vavlkyngiitdtikswrnnilrtqesecacvngscftvmtdgpsngqasykifriekgk
    ivksvemnapnyhyeecscypdsseitcvcrdnwhgsnrpwvsfnqnleyqigyicsgif
    gdnprpndktgscgpvssngangvkgfsfkygngvwigrtksissrngfemiwdpngwtg
    tdnnfsikqdivginewsgysgsfvqhpeltgldcirpcfwvelirgrpkentiwtsgss
    isfcgvnsdtvgwswpdgaelpftidk
    

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4b7rD (D:)
    vklagnsslcpvsgwaiyskdnsvrigskgdvfvirepfiscsplecrtffltqgallnd
    khsngtikdrspyrtlmscpigevpspynsrfesvawsasachdginwltigisgpdnga
    vavlkyngiitdtikswrnnilrtqesecacvngscftvmtdgpsngqasykifriekgk
    ivksvemnapnyhyeecscypdsseitcvcrdnwhgsnrpwvsfnqnleyqigyicsgif
    gdnprpndktgscgpvssngangvkgfsfkygngvwigrtksissrngfemiwdpngwtg
    tdnnfsikqdivginewsgysgsfvqhpeltgldcirpcfwvelirgrpkentiwtsgss
    isfcgvnsdtvgwswpdgaelpftidk