PDB entry 4b7q

View 4b7q on RCSB PDB site
Description: H1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant Explained by Kinetic and Structural Analysis
Class: hydrolase
Keywords: hydrolase, neuraminidase inhibitor, nai, nais, oseltamivir, antiviral resistance
Deposited on 2012-08-21, released 2012-10-03
The last revision prior to the SCOPe 2.05 freeze date was dated 2012-10-10, with a file datestamp of 2012-10-05.
Experiment type: XRAY
Resolution: 2.73 Å
R-factor: 0.1783
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Neuraminidase
    Species: INFLUENZA A VIRUS (A/CALIFORNIA/07/2009(H1N1)) [TaxId:641809]
    Gene:
    Database cross-references and differences (RAF-indexed):
    • Uniprot C7FH46 (Start-468)
      • conflict (350)
    Domains in SCOPe 2.05: d4b7qa_
  • Chain 'B':
    Compound: Neuraminidase
    Species: INFLUENZA A VIRUS (A/CALIFORNIA/07/2009(H1N1)) [TaxId:641809]
    Gene:
    Database cross-references and differences (RAF-indexed):
    • Uniprot C7FH46 (Start-468)
      • conflict (350)
    Domains in SCOPe 2.05: d4b7qb_
  • Chain 'C':
    Compound: Neuraminidase
    Species: INFLUENZA A VIRUS (A/CALIFORNIA/07/2009(H1N1)) [TaxId:641809]
    Gene:
    Database cross-references and differences (RAF-indexed):
    • Uniprot C7FH46 (Start-468)
      • conflict (350)
    Domains in SCOPe 2.05: d4b7qc_
  • Chain 'D':
    Compound: Neuraminidase
    Species: INFLUENZA A VIRUS (A/CALIFORNIA/07/2009(H1N1)) [TaxId:641809]
    Gene:
    Database cross-references and differences (RAF-indexed):
    • Uniprot C7FH46 (Start-468)
      • conflict (350)
    Domains in SCOPe 2.05: d4b7qd_
  • Heterogens: NAG, ZMR, CA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4b7qA (A:)
    mnpnqkiitigsvcmtigmanlilqigniisiwishsiqlgnqnqietcnqsvityennt
    wvnqtyvnisntnfaagqsvvsvklagnsslcpvsgwaiyskdnsvrigskgdvfvirep
    fiscsplecrtffltqgallndkhsngtikdrspyrtlmscpigevpspynsrfesvaws
    asachdginwltigisgpdngavavlkyngiitdtikswrnnilrtqesecacvngscft
    vmtdgpsngqasykifriekgkivksvemnapnyhyeecscypdsseitcvcrdnwhgsn
    rpwvsfnqnleyqigyicsgifgdnprpndktgscgpvssngangvkgfsfkygngvwig
    rtksissrngfemiwdpngwtgtdnnfsikqdivginewsgysgsfvqhpeltgldcirp
    cfwvelirgrpkentiwtsgssisfcgvnsdtvgwswpdgaelpftidk
    

    Sequence, based on observed residues (ATOM records): (download)
    >4b7qA (A:)
    vklagnsslcpvsgwaiyskdnsvrigskgdvfvirepfiscsplecrtffltqgallnd
    khsngtikdrspyrtlmscpigevpspynsrfesvawsasachdginwltigisgpdnga
    vavlkyngiitdtikswrnnilrtqesecacvngscftvmtdgpsngqasykifriekgk
    ivksvemnapnyhyeecscypdsseitcvcrdnwhgsnrpwvsfnqnleyqigyicsgif
    gdnprpndktgscgpvssngangvkgfsfkygngvwigrtksissrngfemiwdpngwtg
    tdnnfsikqdivginewsgysgsfvqhpeltgldcirpcfwvelirgrpkentiwtsgss
    isfcgvnsdtvgwswpdgaelpftidk
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4b7qB (B:)
    mnpnqkiitigsvcmtigmanlilqigniisiwishsiqlgnqnqietcnqsvityennt
    wvnqtyvnisntnfaagqsvvsvklagnsslcpvsgwaiyskdnsvrigskgdvfvirep
    fiscsplecrtffltqgallndkhsngtikdrspyrtlmscpigevpspynsrfesvaws
    asachdginwltigisgpdngavavlkyngiitdtikswrnnilrtqesecacvngscft
    vmtdgpsngqasykifriekgkivksvemnapnyhyeecscypdsseitcvcrdnwhgsn
    rpwvsfnqnleyqigyicsgifgdnprpndktgscgpvssngangvkgfsfkygngvwig
    rtksissrngfemiwdpngwtgtdnnfsikqdivginewsgysgsfvqhpeltgldcirp
    cfwvelirgrpkentiwtsgssisfcgvnsdtvgwswpdgaelpftidk
    

    Sequence, based on observed residues (ATOM records): (download)
    >4b7qB (B:)
    vklagnsslcpvsgwaiyskdnsvrigskgdvfvirepfiscsplecrtffltqgallnd
    khsngtikdrspyrtlmscpigevpspynsrfesvawsasachdginwltigisgpdnga
    vavlkyngiitdtikswrnnilrtqesecacvngscftvmtdgpsngqasykifriekgk
    ivksvemnapnyhyeecscypdsseitcvcrdnwhgsnrpwvsfnqnleyqigyicsgif
    gdnprpndktgscgpvssngangvkgfsfkygngvwigrtksissrngfemiwdpngwtg
    tdnnfsikqdivginewsgysgsfvqhpeltgldcirpcfwvelirgrpkentiwtsgss
    isfcgvnsdtvgwswpdgaelpftidk
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >4b7qC (C:)
    mnpnqkiitigsvcmtigmanlilqigniisiwishsiqlgnqnqietcnqsvityennt
    wvnqtyvnisntnfaagqsvvsvklagnsslcpvsgwaiyskdnsvrigskgdvfvirep
    fiscsplecrtffltqgallndkhsngtikdrspyrtlmscpigevpspynsrfesvaws
    asachdginwltigisgpdngavavlkyngiitdtikswrnnilrtqesecacvngscft
    vmtdgpsngqasykifriekgkivksvemnapnyhyeecscypdsseitcvcrdnwhgsn
    rpwvsfnqnleyqigyicsgifgdnprpndktgscgpvssngangvkgfsfkygngvwig
    rtksissrngfemiwdpngwtgtdnnfsikqdivginewsgysgsfvqhpeltgldcirp
    cfwvelirgrpkentiwtsgssisfcgvnsdtvgwswpdgaelpftidk
    

    Sequence, based on observed residues (ATOM records): (download)
    >4b7qC (C:)
    vklagnsslcpvsgwaiyskdnsvrigskgdvfvirepfiscsplecrtffltqgallnd
    khsngtikdrspyrtlmscpigevpspynsrfesvawsasachdginwltigisgpdnga
    vavlkyngiitdtikswrnnilrtqesecacvngscftvmtdgpsngqasykifriekgk
    ivksvemnapnyhyeecscypdsseitcvcrdnwhgsnrpwvsfnqnleyqigyicsgif
    gdnprpndktgscgpvssngangvkgfsfkygngvwigrtksissrngfemiwdpngwtg
    tdnnfsikqdivginewsgysgsfvqhpeltgldcirpcfwvelirgrpkentiwtsgss
    isfcgvnsdtvgwswpdgaelpftidk
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >4b7qD (D:)
    mnpnqkiitigsvcmtigmanlilqigniisiwishsiqlgnqnqietcnqsvityennt
    wvnqtyvnisntnfaagqsvvsvklagnsslcpvsgwaiyskdnsvrigskgdvfvirep
    fiscsplecrtffltqgallndkhsngtikdrspyrtlmscpigevpspynsrfesvaws
    asachdginwltigisgpdngavavlkyngiitdtikswrnnilrtqesecacvngscft
    vmtdgpsngqasykifriekgkivksvemnapnyhyeecscypdsseitcvcrdnwhgsn
    rpwvsfnqnleyqigyicsgifgdnprpndktgscgpvssngangvkgfsfkygngvwig
    rtksissrngfemiwdpngwtgtdnnfsikqdivginewsgysgsfvqhpeltgldcirp
    cfwvelirgrpkentiwtsgssisfcgvnsdtvgwswpdgaelpftidk
    

    Sequence, based on observed residues (ATOM records): (download)
    >4b7qD (D:)
    vklagnsslcpvsgwaiyskdnsvrigskgdvfvirepfiscsplecrtffltqgallnd
    khsngtikdrspyrtlmscpigevpspynsrfesvawsasachdginwltigisgpdnga
    vavlkyngiitdtikswrnnilrtqesecacvngscftvmtdgpsngqasykifriekgk
    ivksvemnapnyhyeecscypdsseitcvcrdnwhgsnrpwvsfnqnleyqigyicsgif
    gdnprpndktgscgpvssngangvkgfsfkygngvwigrtksissrngfemiwdpngwtg
    tdnnfsikqdivginewsgysgsfvqhpeltgldcirpcfwvelirgrpkentiwtsgss
    isfcgvnsdtvgwswpdgaelpftidk