PDB entry 4aze

View 4aze on RCSB PDB site
Description: Human DYRK1A in complex with Leucettine L41
Class: transferase
Keywords: transferase
Deposited on 2012-06-25, released 2012-09-05
The last revision prior to the SCOPe 2.08 freeze date was dated 2012-11-21, with a file datestamp of 2012-11-16.
Experiment type: XRAY
Resolution: 3.15 Å
R-factor: 0.21904
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dual specificity tyrosine-phosphorylation-regulated kinase 1a
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: dual specificity tyrosine-phosphorylation-regulated kinase 1a
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4azeb_
  • Chain 'C':
    Compound: dual specificity tyrosine-phosphorylation-regulated kinase 1a
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: dual specificity tyrosine-phosphorylation-regulated kinase 1a
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4AZE (0-3)
  • Chain 'F':
    Compound: dual specificity tyrosine-phosphorylation-regulated kinase 1a
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4AZE (0-3)
  • Chain 'G':
    Compound: dual specificity tyrosine-phosphorylation-regulated kinase 1a
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4AZE (0-3)
  • Heterogens: 3RA

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4azeB (B:)
mhhhhhhssgvdlgtenlyfqsmsshkkerkvyndgydddnydyivkngekwmdryeids
ligkgsfgqvvkaydrveqewvaikiiknkkaflnqaqievrllelmnkhdtemkyyivh
lkrhfmfrnhlclvfemlsynlydllrntnfrgvslnltrkfaqqmctallflatpelsi
ihcdlkpenillcnpkrsaikivdfgsscqlgqriyqyiqsrfyrspevllgmpydlaid
mwslgcilvemhtgeplfsganevdqmnkivevlgippahildqapkarkffeklpdgtw
nlkktkdgkreykppgtrklhnilgvetggpggrragesghtvadylkfkdlilrmldyd
pktriqpyyalqhsffkktade

    Sequence, based on observed residues (ATOM records): (download) 
    >4azeB (B:)
vyndgydddnydyivkngekwmdryeidsligkgsfgqvvkaydrveqewvaikiiknkk
aflnqaqievrllelmnkhdtemkyyivhlkrhfmfrnhlclvfemlsynlydllrntnf
rgvslnltrkfaqqmctallflatpelsiihcdlkpenillcnpkrsaikivdfgsscql
gqriyqyiqsrfyrspevllgmpydlaidmwslgcilvemhtgeplfsganevdqmnkiv
evlgippahildqapkarkffeklpdgtwnlkktkdgkreykppgtrklhnilgvetggp
ggrragesghtvadylkfkdlilrmldydpktriqpyyalqhsffkk

  • Chain 'C':
    No sequence available.

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    No sequence available.