PDB entry 4ark
View 4ark on RCSB PDB site
Description: crystal structure of the catalytic domain of human map kinase kinase 1 (mek1) in complex with a small molecule inhibitor and ADP
Class: transferase
Keywords: transferase, kinase, inhibitor
Deposited on
2012-04-24, released
2013-03-06
The last revision prior to the SCOPe 2.05 freeze date was dated
2013-04-17, with a file datestamp of
2013-04-12.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.17395
AEROSPACI score: 0.33
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Dual specificity mitogen-activated protein kinase kinase 1
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d4arka_ - Heterogens: ADP, MG, M3K, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4arkA (A:)
melkdddfekiselgagnggvvfkvshkpsglvmarklihleikpairnqiirelqvlhe
cnspyivgfygafysdgeisicmehmdggsldqvlkkagripeqilgkvsiavikgltyl
rekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlidsmansfvgtrsymsperlqgthy
svqsdiwsmglslvemavgrypipppdakelelmfgcqvegdaaetpprprtpgrplssy
gmdsrppmaifelldyivnepppklpsgvfslefqdfvnkcliknpaeradlkqlmvhaf
ikrsdaeevdfagwlcstiglnqpstpthaagvlehhhhhh
Sequence, based on observed residues (ATOM records): (download)
>4arkA (A:)
melkdddfekiselgagnggvvfkvshkpsglvmarklihleikpairnqiirelqvlhe
cnspyivgfygafysdgeisicmehmdggsldqvlkkagripeqilgkvsiavikgltyl
rekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlidsmansfvgtrsymsperlqgthy
svqsdiwsmglslvemavgrypipppdakelelmfpmaifelldyivnepppklpsgvfs
lefqdfvnkcliknpaeradlkqlmvhafikrsdaeevdfagwlcstigln