PDB entry 4aqc

View 4aqc on RCSB PDB site
Description: Triazolopyridine-based Inhibitor of Janus Kinase 2
Class: transferase
Keywords: transferase, ATP-binding
Deposited on 2012-04-16, released 2012-04-25
The last revision prior to the SCOPe 2.06 freeze date was dated 2012-06-27, with a file datestamp of 2012-06-22.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.17833
AEROSPACI score: 0.48 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase JAK2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4aqca_
  • Chain 'B':
    Compound: Tyrosine-protein kinase JAK2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4aqcb_
  • Heterogens: 88A, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4aqcA (A:)
gamafedrdptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteeh
lrdfereieilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhi
kllqytsqickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvk
epgespifwyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqg
qmivfhliellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnma
g

    Sequence, based on observed residues (ATOM records): (download) 
    >4aqcA (A:)
tqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdfereiei
lkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhikllqytsqic
kgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepgespifwy
apeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivfhliel
lknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnmag

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4aqcB (B:)
gamafedrdptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteeh
lrdfereieilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhi
kllqytsqickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvk
epgespifwyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqg
qmivfhliellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnma
g

    Sequence, based on observed residues (ATOM records): (download) 
    >4aqcB (B:)
fedrdptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdf
ereieilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhikllq
ytsqickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepge
spifwyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmiv
fhliellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnmag