PDB entry 4app

View 4app on RCSB PDB site
Description: Crystal Structure of the Human p21-Activated Kinase 4 in Complex with (S)-N-(5-(3-benzyl-1-methylpiperazine-4-carbonyl)-6,6-dimethyl-1,4,5, 6-tetrahydropyrrolo(3,4-c)pyrazol-3-yl)-3-phenoxybenzamide
Class: transferase
Keywords: transferase, protein kinase
Deposited on 2012-04-04, released 2012-06-06
The last revision prior to the SCOPe 2.05 freeze date was dated 2012-06-06, with a file datestamp of 2012-06-01.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.188
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: serine/threonine-protein kinase pak 4
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot O96013 (4-295)
      • expression tag (3)
    Domains in SCOPe 2.05: d4appa_
  • Heterogens: N53, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4appA (A:)
gshmsheqfraalqlvvdpgdprsyldnfikigegstgivciatvrssgklvavkkmdlr
kqqrrellfnevvimrdyqhenvvemynsylvgdelwvvmefleggaltdivthtrmnee
qiaavclavlqalsvlhaqgvihrdiksdsillthdgrvklsdfgfcaqvskevprrksl
vgtpywmapelisrlpygpevdiwslgimviemvdgeppyfnepplkamkmirdnlpprl
knlhkvspslkgfldrllvrdpaqrataaellkhpflakagppasivplmrqnrtr

    Sequence, based on observed residues (ATOM records): (download) 
    >4appA (A:)
msheqfraalqlvvdpgdprsyldnfikigegstgivciatvrssgklvavkkmdlrkqq
rrellfnevvimrdyqhenvvemynsylvgdelwvvmefleggaltdivthtrmneeqia
avclavlqalsvlhaqgvihrdiksdsillthdgrvklsdfgfcaqvskevprrkslvgt
pywmapelisrlpygpevdiwslgimviemvdgeppyfnepplkamkmirdnlpprlknl
hkvspslkgfldrllvrdpaqrataaellkhpflakagppasivplmrqnrtr