PDB entry 4aoy

View 4aoy on RCSB PDB site
Description: Open CtIDH. The complex structures of Isocitrate dehydrogenase from Clostridium thermocellum and Desulfotalea psychrophila, support a new active site locking mechanism
Class: oxidoreductase
Keywords: oxidoreductase, temperature adaptation, thermophilic, psychrophilic, nadp+ selectivity, domain movements
Deposited on 2012-03-30, released 2012-04-25
The last revision prior to the SCOPe 2.06 freeze date was dated 2013-05-22, with a file datestamp of 2013-05-17.
Experiment type: XRAY
Resolution: 2.35 Å
R-factor: 0.21093
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Isocitrate dehydrogenase [NADP]
    Species: Clostridium thermocellum [TaxId:1515]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4aoya_
  • Chain 'B':
    Compound: Isocitrate dehydrogenase [NADP]
    Species: Clostridium thermocellum [TaxId:1515]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4aoyb_
  • Chain 'C':
    Compound: Isocitrate dehydrogenase [NADP]
    Species: Clostridium thermocellum [TaxId:1515]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4aoyc_
  • Chain 'D':
    Compound: Isocitrate dehydrogenase [NADP]
    Species: Clostridium thermocellum [TaxId:1515]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4aoyd_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4aoyA (A:)
mskikmkvplvemdgdemtriiwrlikenllepyielnteyydlglenrdktedqvtida
araiqkygvgvkcatitpnaqrveeynlkkmwkspngtiraildgtvfrapivvnsikpf
vkgwkkpisiarhaygdvyknveyyvpsagkaelvftsengevsrqtihefdgpgvimgm
hntdksirsfaracfnyaldmnqdlwfstkdtisktydhrfkdifqeiyeneykekfeak
nlqyfytliddavariirseggmvwacknydgdvmsdmvasafgslammtsvlvspdgky
efeaahgtvtrhyykhlkgeetstnsmatifawtgalkkrgeldgikelvdfatkleqas
vqtiengvmtkdlaslsevpekkivntedflkeirktfegma

    Sequence, based on observed residues (ATOM records): (download) 
    >4aoyA (A:)
skikmkvplvemdgdemtriiwrlikenllepyielnteyydlglenrdktedqvtidaa
raiqkygvgvkcatitpnaqrveeynlkkmwkspngtiraildgtvfrapivvnsikpfv
kgwkkpisiarhknveyyvpsagkaelvftsengevsrqtihefdgpgvimgmhntdksi
rsfaracfnyaldmnqdlwfstkdtisktydhrfkdifqeiyeneykekfeaknlqyfyt
liddavariirseggmvwackndgdvmsdmvasafgslammtsvlvspdgkyefeatstn
smatifawtgalkkrgeldgikelvdfatkleqasvqtiengvmtkdlaslsevpekkiv
ntedflkeirktfegm

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4aoyB (B:)
mskikmkvplvemdgdemtriiwrlikenllepyielnteyydlglenrdktedqvtida
araiqkygvgvkcatitpnaqrveeynlkkmwkspngtiraildgtvfrapivvnsikpf
vkgwkkpisiarhaygdvyknveyyvpsagkaelvftsengevsrqtihefdgpgvimgm
hntdksirsfaracfnyaldmnqdlwfstkdtisktydhrfkdifqeiyeneykekfeak
nlqyfytliddavariirseggmvwacknydgdvmsdmvasafgslammtsvlvspdgky
efeaahgtvtrhyykhlkgeetstnsmatifawtgalkkrgeldgikelvdfatkleqas
vqtiengvmtkdlaslsevpekkivntedflkeirktfegma

    Sequence, based on observed residues (ATOM records): (download) 
    >4aoyB (B:)
kikmkvplvemdgdemtriiwrlikenllepyielnteyydlglenrdktedqvtidaar
aiqkygvgvkcatitpnaqrveeynlkkmwkspngtiraildgtvfrapivvnsikpfvk
gwkkpisiarhknveyyvpsagkaelvftsengevsrqtihefdgpgvimgmhntdksir
sfaracfnyaldmnqdlwfstktydhrfkdifqeiyeneykekfeaknlqyfytliddav
ariirseggmvwacknydgdvmsdmvasafgslammtsvlvspdgkyefeaatstnsmat
ifawtgalkkrgeldgikelvdfatkleqasvqtiengvmtkdlaslsevpekkivnted
flkeirktfegm

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4aoyC (C:)
mskikmkvplvemdgdemtriiwrlikenllepyielnteyydlglenrdktedqvtida
araiqkygvgvkcatitpnaqrveeynlkkmwkspngtiraildgtvfrapivvnsikpf
vkgwkkpisiarhaygdvyknveyyvpsagkaelvftsengevsrqtihefdgpgvimgm
hntdksirsfaracfnyaldmnqdlwfstkdtisktydhrfkdifqeiyeneykekfeak
nlqyfytliddavariirseggmvwacknydgdvmsdmvasafgslammtsvlvspdgky
efeaahgtvtrhyykhlkgeetstnsmatifawtgalkkrgeldgikelvdfatkleqas
vqtiengvmtkdlaslsevpekkivntedflkeirktfegma

    Sequence, based on observed residues (ATOM records): (download) 
    >4aoyC (C:)
skikmkvplvemdgdemtriiwrlikenllepyielnteyydlglenrdktedqvtidaa
raiqkygvgvkcatitpnaqrveeynlkkmwkspngtiraildgtvfrapivvnsikpfv
kgwkkpisiarhnveyyvpsagkaelvftsengevsrqtihefdgpgvimgmhntdksir
sfaracfnyaldmnqdlwfstkdtisktydhrfkdifqeiyeneykekfeaknlqyfytl
iddavariirseggmvwackndvmsdmvasafgslammtsvlvspdgkyefeaansmati
fawtgalkkrgeldgikelvdfatkleqasvqtiengvmtkdlaslsevpekkivntedf
lkeirktfegm

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4aoyD (D:)
mskikmkvplvemdgdemtriiwrlikenllepyielnteyydlglenrdktedqvtida
araiqkygvgvkcatitpnaqrveeynlkkmwkspngtiraildgtvfrapivvnsikpf
vkgwkkpisiarhaygdvyknveyyvpsagkaelvftsengevsrqtihefdgpgvimgm
hntdksirsfaracfnyaldmnqdlwfstkdtisktydhrfkdifqeiyeneykekfeak
nlqyfytliddavariirseggmvwacknydgdvmsdmvasafgslammtsvlvspdgky
efeaahgtvtrhyykhlkgeetstnsmatifawtgalkkrgeldgikelvdfatkleqas
vqtiengvmtkdlaslsevpekkivntedflkeirktfegma

    Sequence, based on observed residues (ATOM records): (download) 
    >4aoyD (D:)
skikmkvplvemdgdemtriiwrlikenllepyielnteyydlglenrdktedqvtidaa
raiqkygvgvkcatitpnaqrveeynlkkmwkspngtiraildgtvfrapivvnsikpfv
kgwkkpisiarhaygdnveyyvpsagkaelvftsengevsrqtihefdgpgvimgmhntd
ksirsfaracfnyaldmnqdlwfstkdtisktydhrfkdifqeiyeneykekfeaknlqy
fytliddavariirseggmvwackndvmsdmvasafgslammtsvlvspdgkyefeaans
matifawtgalkkrgeldgikelvdfatkleqasvqtiengvmtkdlaslsevpekkivn
tedflkeirktfegm