PDB entry 4aou

View 4aou on RCSB PDB site
Description: CtIDH bound to NADP. The complex structures of Isocitrate dehydrogenase from Clostridium thermocellum and Desulfotalea psychrophila, support a new active site locking mechanism
Class: oxidoreductase
Keywords: oxidoreductase, temperature adaptation, thermophilic, psychrophilic, nadp+ selectivity, domain movements
Deposited on 2012-03-30, released 2012-07-11
The last revision prior to the SCOPe 2.04 freeze date was dated 2013-05-22, with a file datestamp of 2013-05-17.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.19197
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Isocitrate dehydrogenase [NADP]
    Species: Clostridium thermocellum [TaxId:1515]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d4aoua_
  • Heterogens: ICT, MG, NAP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4aouA (A:)
mskikmkvplvemdgdemtriiwrlikenllepyielnteyydlglenrdktedqvtida
araiqkygvgvkcatitpnaqrveeynlkkmwkspngtiraildgtvfrapivvnsikpf
vkgwkkpisiarhaygdvyknveyyvpsagkaelvftsengevsrqtihefdgpgvimgm
hntdksirsfaracfnyaldmnqdlwfstkdtisktydhrfkdifqeiyeneykekfeak
nlqyfytliddavariirseggmvwacknydgdvmsdmvasafgslammtsvlvspdgky
efeaahgtvtrhyykhlkgeetstnsmatifawtgalkkrgeldgikelvdfatkleqas
vqtiengvmtkdlaslsevpekkivntedflkeirktfegma

    Sequence, based on observed residues (ATOM records): (download) 
    >4aouA (A:)
skikmkvplvemdgdemtriiwrlikenllepyielnteyydlglenrdktedqvtidaa
raiqkygvgvkcatitpnaqrveeynlkkmwkspngtiraildgtvfrapivvnsikpfv
kgwkkpisiarhaygdvyknveyyvpsagkaelvftsengevsrqtihefdgpgvimgmh
ntdksirsfaracfnyaldmnqdlwfstkdtisktydhrfkdifqeiyeneykekfeakn
lqyfytliddavariirseggmvwacknydgdvmsdmvasafgslammtsvlvspdgkye
feaahgtvtrhyykhlkgeetstnsmatifawtgalkkrgeldgikelvdfatkleqasv
qtiengvmtkdlaslsevpekkivntedflkeirktfegma