PDB entry 4anw

View 4anw on RCSB PDB site
Description: Complexes of PI3Kgamma with isoform selective inhibitors.
Class: transferase
Keywords: transferase
Deposited on 2012-03-22, released 2012-05-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-05-08, with a file datestamp of 2019-05-03.
Experiment type: XRAY
Resolution: 2.31 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P48736 (5-End)
      • expression tag (4)
    Domains in SCOPe 2.08: d4anwa1, d4anwa2, d4anwa3, d4anwa4, d4anwa5
  • Heterogens: SO4, O92, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4anwA (A:)
mllgsseesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyam
hpwvtskplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmakkksl
mdipesqseqdfvlrvcgrdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldev
rkeewplvddctgvtgyheqltihgkdhesvftvslwdcdrkfrvkirgidipvlprntd
ltvfveaniqhgqqvlcqrrtspkpfteevlwnvwlefsikikdlpkgallnlqiycgka
palsskasaespsseskgkvqllyyvnlllidhrfllrrgeyvlhmwqisgkgedqgsfn
adkltsatnpdkensmsisilldnychpialpkhqptpdpegdrvraempnqlrkqleai
iatdplnpltaedkellwhfryeslkhpkaypklfssvkwgqqeivaktyqllarrevwd
qsaldvgltmqlldcnfsdenvraiavqklesledddvlhyllqlvqavkfepyhdsala
rfllkrglrnkrighflfwflrseiaqsrhyqqrfavileaylrgcgtamlhdftqqvqv
iemlqkvtldikslsaekydvssqvisqlkqklenlqnsqlpesfrvpydpglkagalai
ekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqilrimesiwete
sldlcllpygcistgdkigmieivkdattiakiqqstvgntgafkdevlnhwlkekspte
ekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidfghilgnyksflgi
nkervpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtg
mpqltskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwflhlvlgikqge
khsaefglvprgsghhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4anwA (A:)
sseesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwv
tskplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmeqdfvlrvcg
rdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrkecdrkfrvkirgidip
vlprntdltvfveaniqhgqqvlcqrrtspkpfteevlwnvwlefsikikdlpkgallnl
qiycqllyyvnlllidhrfllrrgeyvlhmwqisgfnadkltsatnpdkensmsisilld
nraempnqlrkqleaiiatdplnpltaedkellwhfryeslkhpkaypklfssvkwgqqe
ivaktyqllarrevwdqsaldvgltmqlldcnfsdenvraiavqklesledddvlhyllq
lvqavkfepyhdsalarfllkrglrnkrighflfwflrseiaqsrhyqqrfavileaylr
gcgtamlhdftqqvqviemlqkvtldikslsaekydvssqvisqlkqklenlqnsqlpes
frvpydpglkagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdm
lilqilrimesiwetesldlcllpygcistgdkigmieivkdattiakiqqstvgntgaf
kdevlnhwlkekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfh
idfghiervpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmm
lmtgmpqltskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwf