PDB entry 4ans

View 4ans on RCSB PDB site
Description: Structure of L1196M,G1269A Double Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib
Class: transferase
Keywords: transferase
Deposited on 2012-03-22, released 2013-03-27
The last revision prior to the SCOPe 2.05 freeze date was dated 2013-03-27, with a file datestamp of 2013-03-22.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: 0.201
AEROSPACI score: 0.49 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ALK tyrosine kinase receptor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UM73 (23-End)
      • engineered mutation (126)
      • engineered mutation (199)
    Domains in SCOPe 2.05: d4ansa_
  • Heterogens: VGH, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4ansA (A:)
mahhhhhhdygipttenlyfqgsnpnycfagktssisdlkevprknitlirglghgafge
vyegqvsgmpndpsplqvavktlpevcseqdeldflmealiiskfnhqnivrcigvslqs
lprfilmelmaggdlksflretrprpsqpsslamldllhvardiacgcqyleenhfihrd
iaarnclltcpgpgrvakiadfgmardiyrasyyrkggcamlpvkwmppeafmegiftsk
tdtwsfgvllweifslgympypsksnqevlefvtsggrmdppkncpgpvyrimtqcwqhq
pedrpnfaiilerieyctqdpdvintalpieygplveeeekv

    Sequence, based on observed residues (ATOM records): (download) 
    >4ansA (A:)
npnycfagktssisdlkevprknitlirglgafgevyegqvplqvavktlpevcseqdel
dflmealiiskfnhqnivrcigvslqslprfilmelmaggdlksflretrprpsqpssla
mldllhvardiacgcqyleenhfihrdiaarnclltcpgpgrvakiadfgmardiyrggc
amlpvkwmppeafmegiftsktdtwsfgvllweifslgympypsksnqevlefvtsggrm
dppkncpgpvyrimtqcwqhqpedrpnfaiilerieyctqdpdvintalpieyg