PDB entry 4anl

View 4anl on RCSB PDB site
Description: Structure of G1269A Mutant Anaplastic Lymphoma Kinase
Class: transferase
Keywords: transferase, crizotinib
Deposited on 2012-03-20, released 2013-03-27
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-05-08, with a file datestamp of 2019-05-03.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: N/A
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ALK tyrosine kinase receptor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UM73
      • engineered mutation (199)
    Domains in SCOPe 2.08: d4anla_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4anlA (A:)
mahhhhhhdygipttenlyfqgsnpnycfagktssisdlkevprknitlirglghgafge
vyegqvsgmpndpsplqvavktlpevcseqdeldflmealiiskfnhqnivrcigvslqs
lprfillelmaggdlksflretrprpsqpsslamldllhvardiacgcqyleenhfihrd
iaarnclltcpgpgrvakiadfgmardiyrasyyrkggcamlpvkwmppeafmegiftsk
tdtwsfgvllweifslgympypsksnqevlefvtsggrmdppkncpgpvyrimtqcwqhq
pedrpnfaiilerieyctqdpdvintalpieygplveeeekv

    Sequence, based on observed residues (ATOM records): (download) 
    >4anlA (A:)
pnycfagktssisdlkevprknitlirglgafgevyegqvplqvavktlpevcseqdeld
flmealiiskfnhqnivrcigvslqslprfillelmaggdlksflretrprpsqpsslam
ldllhvardiacgcqyleenhfihrdiaarnclltcpgpgrvakiadfgmardiyrggca
mlpvkwmppeafmegiftsktdtwsfgvllweifslgympypsksnqevlefvtsggrmd
ppkncpgpvyrimtqcwqhqpedrpnfaiilerieyctqdpdvintalpieyg