PDB entry 4ank
View 4ank on RCSB PDB site
Description: Crystallographic study of novel transthyretin ligands exhibiting negative-cooperativity between two T4 binding sites.
Class: hormone binding protein
Keywords: hormone binding protein, thyroxine transport protein, hormone, amyloidosis inhibition
Deposited on
2012-03-20, released
2012-09-26
The last revision prior to the SCOPe 2.08 freeze date was dated
2019-07-17, with a file datestamp of
2019-07-12.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: N/A
AEROSPACI score: 0.4
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Transthyretin
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4anka_ - Chain 'B':
Compound: Transthyretin
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4ankb_ - Heterogens: HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4ankA (A:)
mashrllllclaglvfvseagptgtgeskcplmvkvldavrgspainvavhvfrkaaddt
wepfasgktsesgelhgltteeefvegiykveidtksywkalgispfhehaevvftands
gprrytiaallspysysttavvtnpke
Sequence, based on observed residues (ATOM records): (download)
>4ankA (A:)
cplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltteeefvegiy
kveidtksywkalgispfhehaevvftandsgprrytiaallspysysttavvtnp
- Chain 'B':
Sequence, based on SEQRES records: (download)
>4ankB (B:)
mashrllllclaglvfvseagptgtgeskcplmvkvldavrgspainvavhvfrkaaddt
wepfasgktsesgelhgltteeefvegiykveidtksywkalgispfhehaevvftands
gprrytiaallspysysttavvtnpke
Sequence, based on observed residues (ATOM records): (download)
>4ankB (B:)
cplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltteeefvegiy
kveidtksywkalgispfhehaevvftandsgprrytiaallspysysttavvtn