PDB entry 4agp
View 4agp on RCSB PDB site
Description: Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5176
Class: cell cycle
Keywords: transcription, cell cycle, apoptosis, cancer mutation, surface crevice, protein folding, aggregation, mutant rescue, small-molecule drug, protein stabilization, halogen bonding
Deposited on
2012-01-30, released
2012-03-21
The last revision prior to the SCOPe 2.07 freeze date was dated
2012-05-02, with a file datestamp of
2012-04-27.
Experiment type: XRAY
Resolution: 1.5 Å
R-factor: 0.1692
AEROSPACI score: 0.65
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Cellular tumor antigen p53
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P04637
- engineered mutation (39)
- engineered mutation (109)
- engineered mutation (126)
- engineered mutation (145)
- engineered mutation (174)
Domains in SCOPe 2.07: d4agpa_ - Chain 'B':
Compound: Cellular tumor antigen p53
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P04637 (0-End)
- engineered mutation (39)
- engineered mutation (109)
- engineered mutation (126)
- engineered mutation (145)
- engineered mutation (174)
Domains in SCOPe 2.07: d4agpb_ - Heterogens: P51, ZN, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4agpA (A:)
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnklfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlraeylddrntfr
hsvvvpceppevgsdcttihynymcysscmggmnrrpiltiitledssgnllgrdsfevr
vcacpgrdrrteeenlrkkgephhelppgstkralpnnt
Sequence, based on observed residues (ATOM records): (download)
>4agpA (A:)
svpsqktyqgsygfrlgflhsgtaksvtctyspalnklfcqlaktcpvqlwvdstpppgt
rvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlraeylddrntfrhs
vvvpceppevgsdcttihynymcysscmggmnrrpiltiitledssgnllgrdsfevrvc
acpgrdrrteeenlrk
- Chain 'B':
Sequence, based on SEQRES records: (download)
>4agpB (B:)
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnklfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlraeylddrntfr
hsvvvpceppevgsdcttihynymcysscmggmnrrpiltiitledssgnllgrdsfevr
vcacpgrdrrteeenlrkkgephhelppgstkralpnnt
Sequence, based on observed residues (ATOM records): (download)
>4agpB (B:)
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnklfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlraeylddrntfr
hsvvvpceppevgsdcttihynymcysscmggmnrrpiltiitledssgnllgrdsfevr
vcacpgrdrrteeenlr