PDB entry 4ag8
View 4ag8 on RCSB PDB site
Description: CRYSTAL STRUCTURE OF THE VEGFR2 KINASE DOMAIN IN COMPLEX WITH AXITINIB (AG-013736) (N-Methyl-2-(3-((E)-2-pyridin-2-yl-vinyl)-1H- indazol-6-ylsulfanyl)-benzamide)
Class: transferase
Keywords: transferase, angiogenesis, nucleotide-binding, inhibitor, phosphorylation, transmembrane
Deposited on
2012-01-24, released
2012-09-26
The last revision prior to the SCOPe 2.03 freeze date was dated
2012-11-14, with a file datestamp of
2012-11-09.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: 0.19726
AEROSPACI score: 0.44
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Vascular endothelial growth factor receptor 2
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.03: d4ag8a_ - Heterogens: AXI, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4ag8A (A:)
mdpdelpldehcerlpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtv
avkmlkegathsehralmselkilihighhlnvvnllgactkpggplmvivefckfgnls
tylrskrnefvpykvapedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnil
lseknvvkicdfglardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvll
weifslgaspypgvkideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfse
lvehlgnllqanaqqd
Sequence, based on observed residues (ATOM records): (download)
>4ag8A (A:)
hcerlpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtvavkmlkegat
hsehralmselkilihighhlnvvnllgactkpggplmvivefckfgnlstylrskrnef
vpyykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvkicdfglard
iykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvllweifslgaspypgvkid
eefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnllqana