PDB entry 4afj

View 4afj on RCSB PDB site
Description: 5-aryl-4-carboxamide-1,3-oxazoles: potent and selective GSK-3 inhibitors
Class: transferase/peptide
Keywords: transferase-peptide complex, kinase
Deposited on 2012-01-19, released 2012-02-29
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-05-29, with a file datestamp of 2019-05-24.
Experiment type: XRAY
Resolution: 1.98 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Glycogen synthase kinase-3 beta
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4afja_
  • Chain 'B':
    Compound: Glycogen synthase kinase-3 beta
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4afjb_
  • Chain 'X':
    Compound: proto-oncogene frat1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'Y':
    Compound: proto-oncogene frat1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: SO4, GOL, SJJ, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4afjA (A:)
kvsrdkdgskvttvvatpgqgpdrpqevsytdtkvigngsfgvvyqaklcdsgelvaikk
vlqdkrfknrelqimrkldhcnivrlryffyssgekkdevylnlvldyvpetvyrvarhy
srakqtlpviyvklymyqlfrslayihsfgichrdikpqnllldpdtavlklcdfgsakq
lvrgepnvsyicsryyrapelifgatdytssidvwsagcvlaelllgqpifpgdsgvdql
veiikvlgtptreqiremnpnytefkfpqikahpwtkvfrprtppeaialcsrlleytpt
arltpleacahsffdelrdpnvklpngrdtpalfnfttqelssnpplatilipphariqa
aastptn

    Sequence, based on observed residues (ATOM records): (download) 
    >4afjA (A:)
kvttvvatpgqgpdrpqevsytdtkvigngsfgvvyqaklcdsgelvaikkvlqfknrel
qimrkldhcnivrlryffysskkdevylnlvldyvpetvyrvarhysrakqtlpviyvkl
ymyqlfrslayihsfgichrdikpqnllldpdtavlklcdfgsakqlvrgepnvsyicsr
yyrapelifgatdytssidvwsagcvlaelllgqpifpgdsgvdqlveiikvlgtptreq
iremnpnytefkfpqikahpwtkvfrprtppeaialcsrlleytptarltpleacahsff
delrdpnvklpngrdtpalfnfttqelssnpplatilipphari

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4afjB (B:)
kvsrdkdgskvttvvatpgqgpdrpqevsytdtkvigngsfgvvyqaklcdsgelvaikk
vlqdkrfknrelqimrkldhcnivrlryffyssgekkdevylnlvldyvpetvyrvarhy
srakqtlpviyvklymyqlfrslayihsfgichrdikpqnllldpdtavlklcdfgsakq
lvrgepnvsyicsryyrapelifgatdytssidvwsagcvlaelllgqpifpgdsgvdql
veiikvlgtptreqiremnpnytefkfpqikahpwtkvfrprtppeaialcsrlleytpt
arltpleacahsffdelrdpnvklpngrdtpalfnfttqelssnpplatilipphariqa
aastptn

    Sequence, based on observed residues (ATOM records): (download) 
    >4afjB (B:)
gskvttvvatpgqgpdrpqevsytdtkvigngsfgvvyqaklcdsgelvaikkvlqknre
lqimrkldhcnivrlryffyssgekkdevylnlvldyvpetvyrvarhysrakqtlpviy
vklymyqlfrslayihsfgichrdikpqnllldpdtavlklcdfgsakqlvrgepnvsyi
csryyrapelifgatdytssidvwsagcvlaelllgqpifpgdsgvdqlveiikvlgtpt
reqiremnpnytefkfpqikahpwtkvfrprtppeaialcsrlleytptarltpleacah
sffdelrdpnvklpngrdtpalfnfttqelssnpplatilipphari

  • Chain 'X':
    No sequence available.

  • Chain 'Y':
    No sequence available.