PDB entry 4a1w

View 4a1w on RCSB PDB site
Description: Crystal structure of alpha-beta foldamer 4c in complex with Bcl-xL
Class: apoptosis/inhibitor
Keywords: apoptosis-inhibitor complex, mimicry
Deposited on 2011-09-20, released 2011-12-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-07-10, with a file datestamp of 2019-07-05.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bcl-2-like protein 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4a1wa1, d4a1wa2
  • Chain 'B':
    Compound: Bcl-2-like protein 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4a1wb1, d4a1wb2
  • Chain 'C':
    Compound: Bcl-2-like protein 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4a1wc_
  • Chain 'D':
    Compound: Bcl-2-like protein 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4a1wd1, d4a1wd2
  • Chain 'P':
    Compound: alpha-beta-foldamer 2c
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 4A1W
  • Chain 'Q':
    Compound: alpha-beta-foldamer 2c
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 4A1W (0-End)
  • Chain 'R':
    Compound: alpha-beta-foldamer 2c
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 4A1W
  • Chain 'S':
    Compound: alpha-beta-foldamer 2c
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 4A1W (0-End)
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4a1wA (A:)
gplgsmsqsnrelvvdflsyklsqkgyswsqmaavkqalreagdefelryrrafsdltsq
lhitpgtayqsfeqvvnelfrdgvnwgrivaffsfggalcvesvdkemqvlvsriaawma
tylndhlepwiqenggwdtfvelygnnaaaesrkgqer

    Sequence, based on observed residues (ATOM records): (download) 
    >4a1wA (A:)
msqsnrelvvdflsyklsqkgyswsqmaavkqalreagdefelryrrafsdltsqlhitp
gtayqsfeqvvnelfrdgvnwgrivaffsfggalcvesvdkemqvlvsriaawmatylnd
hlepwiqenggwdtfvelygn

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4a1wB (B:)
gplgsmsqsnrelvvdflsyklsqkgyswsqmaavkqalreagdefelryrrafsdltsq
lhitpgtayqsfeqvvnelfrdgvnwgrivaffsfggalcvesvdkemqvlvsriaawma
tylndhlepwiqenggwdtfvelygnnaaaesrkgqer

    Sequence, based on observed residues (ATOM records): (download) 
    >4a1wB (B:)
lgsmsqsnrelvvdflsyklsqkgyswsqmaavkqalreagdefelryrrafsdltsqlh
itpgtayqsfeqvvnelfrdgvnwgrivaffsfggalcvesvdkemqvlvsriaawmaty
lndhlepwiqenggwdtfvelygn

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4a1wC (C:)
gplgsmsqsnrelvvdflsyklsqkgyswsqmaavkqalreagdefelryrrafsdltsq
lhitpgtayqsfeqvvnelfrdgvnwgrivaffsfggalcvesvdkemqvlvsriaawma
tylndhlepwiqenggwdtfvelygnnaaaesrkgqer

    Sequence, based on observed residues (ATOM records): (download) 
    >4a1wC (C:)
qsnrelvvdflsyklsqkgyswsqmaavkqalreagdefelryrrafsdltsqlhitpgt
ayqsfeqvvnelfrdgvnwgrivaffsfggalcvesvdkemqvlvsriaawmatylndhl
epwiqenggwdtfvelyg

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4a1wD (D:)
gplgsmsqsnrelvvdflsyklsqkgyswsqmaavkqalreagdefelryrrafsdltsq
lhitpgtayqsfeqvvnelfrdgvnwgrivaffsfggalcvesvdkemqvlvsriaawma
tylndhlepwiqenggwdtfvelygnnaaaesrkgqer

    Sequence, based on observed residues (ATOM records): (download) 
    >4a1wD (D:)
smsqsnrelvvdflsyklsqkgyswsqmaavkqalreagdefelryrrafsdltsqlhit
pgtayqsfeqvvnelfrdgvnwgrivaffsfggalcvesvdkemqvlvsriaawmatyln
dhlepwiqenggwdtfvelyg

  • Chain 'P':
    No sequence available.

  • Chain 'Q':
    No sequence available.

  • Chain 'R':
    No sequence available.

  • Chain 'S':
    No sequence available.