PDB entry 4a07

View 4a07 on RCSB PDB site
Description: human pdk1 kinase domain in complex with allosteric activator ps171 bound to the pif-pocket
Class: transferase
Keywords: transferase, allosteric site
Deposited on 2011-09-08, released 2011-12-07
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-12-21, with a file datestamp of 2011-12-16.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: 0.1609
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 3-phosphoinositide-dependent protein kinase 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot O15530 (Start-310)
      • engineered mutation (239)
      • engineered mutation (243)
    Domains in SCOPe 2.05: d4a07a_
  • Heterogens: ATP, AZ7, MG, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4a07A (A:)
gamdgtaaeprpgagslqhaqpppqprkkrpedfkfgkilgegsfstvvlarelatsrey
aikilekrhiikenkvpyvtrerdvmsrldhpffvklyftfqddeklyfglsyakngell
kyirkigsfdetctrfytaeivsaleylhgkgiihrdlkpenillnedmhiqitdfgtak
vlspeskqaransfvgtaqyvspellteksackssdlwalgciiyqlvaglppfragneg
lifakiikleydfpekffpkardlvekllvldatkrlgceemegygplkahpffesvtwe
nlhqqtppklt

    Sequence, based on observed residues (ATOM records): (download) 
    >4a07A (A:)
rkkrpedfkfgkilgegsfstvvlarelatsreyaikilekrhiikenkvpyvtrerdvm
srldhpffvklyftfqddeklyfglsyakngellkyirkigsfdetctrfytaeivsale
ylhgkgiihrdlkpenillnedmhiqitdfgtakvlspeskqaransfvgtaqyvspell
teksackssdlwalgciiyqlvaglppfragneglifakiikleydfpekffpkardlve
kllvldatkrlgceemegygplkahpffesvtwenlhqqtppklt