SCOPe 2.07: Structural Classification of Proteins

PDB entry 3zxr

View 3zxr on RCSB PDB site
Description: Crystal structure of Mycobacterium Tuberculosis Glutamine Synthetase in complex with tri-substituted imidazole inhibitor (3-(2-tert-butyl- 5-(pyridin-4-yl)-1H-imidazol-4-yl)quinoline) and L-methionine-S- sulfoximine phosphate.
Class: ligase
Keywords: ligase, nucleotide-binding, taut state, rv2220, mt2278, glna1
Deposited on 2011-08-15, released 2012-04-04
The last revision prior to the SCOPe 2.07 freeze date was dated 2012-04-04, with a file datestamp of 2012-03-30.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: 0.22584
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: glutamine synthetase 1
Species: Mycobacterium tuberculosis [TaxId:83332]
Database cross-references and differences (RAF-indexed):
- Uniprot P0A590 (Start-485)
- Uniprot E2UB91 (Start-485)
- Uniprot F2GJU9 (Start-485)
Domains in SCOPe 2.07: d3zxra1, d3zxra2
Chain 'B':
Compound: glutamine synthetase 1
Species: Mycobacterium tuberculosis [TaxId:83332]
Database cross-references and differences (RAF-indexed):
- Uniprot P0A590 (Start-485)
- Uniprot E2UB91 (Start-485)
- Uniprot F2GJU9 (Start-485)
Domains in SCOPe 2.07: d3zxrb1, d3zxrb2
Chain 'C':
Compound: glutamine synthetase 1
Species: Mycobacterium tuberculosis [TaxId:83332]
Database cross-references and differences (RAF-indexed):
- Uniprot P0A590 (Start-485)
- Uniprot E2UB91 (Start-485)
- Uniprot F2GJU9 (Start-485)
Domains in SCOPe 2.07: d3zxrc1, d3zxrc2
Chain 'D':
Compound: glutamine synthetase 1
Species: Mycobacterium tuberculosis [TaxId:83332]
Database cross-references and differences (RAF-indexed):
- Uniprot P0A590 (Start-485)
- Uniprot E2UB91 (Start-485)
- Uniprot F2GJU9 (Start-485)
Domains in SCOPe 2.07: d3zxrd1, d3zxrd2
Chain 'E':
Compound: glutamine synthetase 1
Species: Mycobacterium tuberculosis [TaxId:83332]
Database cross-references and differences (RAF-indexed):
- Uniprot P0A590 (Start-485)
- Uniprot E2UB91 (Start-485)
- Uniprot F2GJU9 (Start-485)
Domains in SCOPe 2.07: d3zxre1, d3zxre2
Chain 'F':
Compound: glutamine synthetase 1
Species: Mycobacterium tuberculosis [TaxId:83332]
Database cross-references and differences (RAF-indexed):
- Uniprot P0A590 (Start-485)
- Uniprot E2UB91 (Start-485)
- Uniprot F2GJU9 (Start-485)
Domains in SCOPe 2.07: d3zxrf1, d3zxrf2
Heterogens: IQ1, MG, P3S, PO4, CL, HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>3zxrA (A:)
mahhhhhhgtektpddvfklakdekveyvdvrfcdlpgimqhftipasafdksvfddgla
fdgssirgfqsihesdmlllpdpetaridpfraaktlninffvhdpftlepysrdprnia
rkaenylistgiadtayfgaeaefyifdsvsfdsrangsfyevdaisgwwntgaateadg
spnrgykvrhkggyfpvapndqyvdlrdkmltnlinsgfilekghhevgsggqaeinyqf
nsllhaaddmqlykyiikntawqngktvtfmpkplfgdngsgmhchqslwkdgaplmyde
tgyaglsdtarhyiggllhhapsllaftnptvnsykrlvpgyeapinlvysqrnrsacvr
ipitgsnpkakrlefrspdssgnpylafsamlmagldgiknkiepqapvdkdlyelppee
aasipqtptqlsdvidrleadheylteggvftndlietwisfkreneiepvnirphpyef
alyydv