PDB entry 3zs5
View 3zs5 on RCSB PDB site
Description: Structural basis for kinase selectivity of three clinical p38alpha inhibitors
Class: transferase
Keywords: transferase, tak-715, scio-469, vx-745, sb-203580
Deposited on
2011-06-23, released
2012-07-04
The last revision prior to the SCOPe 2.05 freeze date was dated
2012-08-15, with a file datestamp of
2012-08-10.
Experiment type: XRAY
Resolution: 1.6 Å
R-factor: 0.18586
AEROSPACI score: 0.59
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Mitogen-activated protein kinase 14
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d3zs5a_ - Heterogens: SB2, BOG, EDO, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3zs5A (A:)
gshsqerptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktglrvavkklsrp
fqsiihakrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivk
cqkltddhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglarhtdde
mtgyvatrwyrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrl
vgtpgaellkkissesarnyiqsltqmpkmnfanvfiganplavdllekmlvldsdkrit
aaqalahayfaqyhdpddepvadpydqsfesrdllidewksltydevisfvpppldqeem
es
Sequence, based on observed residues (ATOM records): (download)
>3zs5A (A:)
hsqerptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktglrvavkklsrpfq
siihakrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcq
kltddhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglatrwyrape
imlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpgaellkkiss
esarnyiqsltqmpkmnfanvfiganplavdllekmlvldsdkritaaqalahayfaqyh
dpddepvadpydqsfesrdllidewksltydevisfvppp