PDB entry 3zkn

View 3zkn on RCSB PDB site
Description: bace2 fab inhibitor complex
Class: immune system/hydrolase
Keywords: immune system-hydrolase complex, fab complex
Deposited on 2013-01-23, released 2013-05-29
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-03-11, with a file datestamp of 2020-03-06.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Beta-secretase 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3zkna_
  • Chain 'B':
    Compound: Beta-secretase 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3zknb_
  • Chain 'C':
    Compound: Fab heavy chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 3ZKN (0-End)
    Domains in SCOPe 2.08: d3zknc_
  • Chain 'D':
    Compound: Fab light chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 3ZKN (0-End)
    Domains in SCOPe 2.08: d3zknd1, d3zknd2
  • Chain 'H':
    Compound: Fab heavy chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 3ZKN (0-End)
    Domains in SCOPe 2.08: d3zknh_
  • Chain 'L':
    Compound: Fab light chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 3ZKN (0-End)
    Domains in SCOPe 2.08: d3zknl1, d3zknl2
  • Heterogens: WZV, DMS, SO4, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3zknA (A:)
anflamvdnlqgdsgrgyylemligtppqklqilvdtgssnfavagtphsyidtyfdter
sstyrskgfdvtvkytqgswtgfvgedlvtipkgfntsflvniatifesenfflpgikwn
gilglayatlakpsssletffdslvtqanipnvfsmqmcgaglpvagsgtnggslvlggi
epslykgdiwytpikeewyyqieilkleiggqslnldcreynadkaivdsgttllrlpqk
vfdavveavaraslipefsdgfwtgsqlacwtnsetpwsyfpkisiylrdenssrsfrit
ilpqlyiqpmmgaglnyecyrfgispstnalvigatvmegfyvifdraqkrvgfaaspca
eiagaavseisgpfstedvasncvpa

    Sequence, based on observed residues (ATOM records): (download) 
    >3zknA (A:)
nflamvdnlqgdsgrgyylemligtppqklqilvdtgssnfavagtphsyidtyfdters
styrskgfdvtvkytqgswtgfvgedlvtipkgfntsflvniatifesenfflpgikwng
ilglayatlakpsssletffdslvtqanipnvfsmqmcganggslvlggiepslykgdiw
ytpikeewyyqieilkleiggqslnldcreynadkaivdsgttllrlpqkvfdavveava
raslipefsdgfwtgsqlacwtnsetpwsyfpkisiylrdenssrsfritilpqlyiqpm
mgaglnyecyrfgispstnalvigatvmegfyvifdraqkrvgfaaspcaeiagaavsei
sgpfstedvasncvp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3zknB (B:)
anflamvdnlqgdsgrgyylemligtppqklqilvdtgssnfavagtphsyidtyfdter
sstyrskgfdvtvkytqgswtgfvgedlvtipkgfntsflvniatifesenfflpgikwn
gilglayatlakpsssletffdslvtqanipnvfsmqmcgaglpvagsgtnggslvlggi
epslykgdiwytpikeewyyqieilkleiggqslnldcreynadkaivdsgttllrlpqk
vfdavveavaraslipefsdgfwtgsqlacwtnsetpwsyfpkisiylrdenssrsfrit
ilpqlyiqpmmgaglnyecyrfgispstnalvigatvmegfyvifdraqkrvgfaaspca
eiagaavseisgpfstedvasncvpa

    Sequence, based on observed residues (ATOM records): (download) 
    >3zknB (B:)
nflamvdnlqgdsgrgyylemligtppqklqilvdtgssnfavagtphsyidtyfdters
styrskgfdvtvkytqgswtgfvgedlvtipkgfntsflvniatifesenfflpgikwng
ilglayatlakpsssletffdslvtqanipnvfsmqmcganggslvlggiepslykgdiw
ytpikeewyyqieilkleiggqslnldcreynadkaivdsgttllrlpqkvfdavveava
raslipefsdgfwtgsqlacwtnsetpwsyfpkisiylrdenssrsfritilpqlyiqpm
mgaglnyecyrfgispstnalvigatvmegfyvifdraqkrvgfaaspcaeiagaavsei
sgpfstedvasncvp

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3zknC (C:)
evqlkesgpvlvapsqslfisctvsgfsltrygvhwvrqspgkglewlgviwaggttnyn
safmsrltiskdnsksqvflkmnslqtddtaiyycvkayrnamdywgqgtsvtvssaktt
apsvyplapvcgdtsgssvtlgclvkgyfpepvtltwnsgslssgvhtfpavlqsdlytl
sssvtvtsstwpsqsitcnvahpasstkvdkkieprgptik

    Sequence, based on observed residues (ATOM records): (download) 
    >3zknC (C:)
evqlkesgpvlvapsqslfisctvsgfsltrygvhwvrqspgkglewlgviwaggttnyn
safmsrltiskdnsksqvflkmnslqtddtaiyycvkayrnamdywgqgtsvtvssaktt
apsvyplapvcgdtsgssvtlgclvkgyfpepvtltwnsgslssgvhtfpavlqsdlytl
sssvtvtsstwpsqsitcnvahpasstkvdkkieprg

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3zknD (D:)
nivlsqspgslavslgqratiscrasksvdtyghsfihwyqqkpgqppnllihlasnles
gvparfsgrgsgtdftltidpveaddaatyycqqnnedpwtfgggtkleikradaaptvs
ifppsseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysms
stltltkdeyerhnsytceathktstspivksfnrnec

    Sequence, based on observed residues (ATOM records): (download) 
    >3zknD (D:)
nivlsqspgslavslgqratiscrasksvdtyghsfihwyqqkpgqppnllihlasnles
gvparfsgrgsgtdftltidpveaddaatyycqqnnedpwtfgggtkleikradaaptvs
ifppsseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysms
stltltkdeyerhnsytceathktstspivksfnrne

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >3zknH (H:)
evqlkesgpvlvapsqslfisctvsgfsltrygvhwvrqspgkglewlgviwaggttnyn
safmsrltiskdnsksqvflkmnslqtddtaiyycvkayrnamdywgqgtsvtvssaktt
apsvyplapvcgdtsgssvtlgclvkgyfpepvtltwnsgslssgvhtfpavlqsdlytl
sssvtvtsstwpsqsitcnvahpasstkvdkkieprgptik

    Sequence, based on observed residues (ATOM records): (download) 
    >3zknH (H:)
evqlkesgpvlvapsqslfisctvsgfsltrygvhwvrqspgkglewlgviwaggttnyn
safmsrltiskdnsksqvflkmnslqtddtaiyycvkayrnamdywgqgtsvtvssaktt
apsvyplapvcgdtsgssvtlgclvkgyfpepvtltwnsgslssgvhtfpavlqsdlytl
sssvtvtsstwpsqsitcnvahpasstkvdkkieprg

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >3zknL (L:)
nivlsqspgslavslgqratiscrasksvdtyghsfihwyqqkpgqppnllihlasnles
gvparfsgrgsgtdftltidpveaddaatyycqqnnedpwtfgggtkleikradaaptvs
ifppsseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysms
stltltkdeyerhnsytceathktstspivksfnrnec

    Sequence, based on observed residues (ATOM records): (download) 
    >3zknL (L:)
nivlsqspgslavslgqratiscrasksvdtyghsfihwyqqkpgqppnllihlasnles
gvparfsgrgsgtdftltidpveaddaatyycqqnnedpwtfgggtkleikradaaptvs
ifppsseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysms
stltltkdeyerhnsytceathktstspivksfnrne