PDB entry 3zep

View 3zep on RCSB PDB site
Description: Crystal Structure of JAK3 Kinase Domain in Complex with a Pyrrolopyrazine-2-phenyl Ether Inhibitor
Class: transferase
Keywords: transferase, stat5, stat6, interleukin-2, common-gamma chain, ATP site kinase inhibitor, cancer, scid, severe combined immunodeficiency
Deposited on 2012-12-06, released 2013-12-11
The last revision prior to the SCOPe 2.06 freeze date was dated 2013-12-11, with a file datestamp of 2013-12-06.
Experiment type: XRAY
Resolution: 2.35 Å
R-factor: 0.22627
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase JAK3
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P52333
      • engineered mutation (227)
      • engineered mutation (235)
    Domains in SCOPe 2.06: d3zepa_
  • Chain 'B':
    Compound: Tyrosine-protein kinase JAK3
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P52333 (Start-287)
      • engineered mutation (235)
    Domains in SCOPe 2.06: d3zepb_
  • Chain 'C':
    Compound: Tyrosine-protein kinase JAK3
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P52333 (Start-287)
      • engineered mutation (227)
      • engineered mutation (235)
    Domains in SCOPe 2.06: d3zepc_
  • Chain 'D':
    Compound: Tyrosine-protein kinase JAK3
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P52333
      • engineered mutation (235)
    Domains in SCOPe 2.06: d3zepd_
  • Heterogens: 1NX, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3zepA (A:)
dptifeerhlkyisqlgkgnfgsvelcrydplgdntgalvavkqlqhsgpdqqrdfqrei
qilkalhsdfivkyrgvsygpgrqslrlvmeylpsgclrdflqrhrarldasrlllyssq
ickgmeylgsrrcvhrdlaarnilveseahvkiadfglakllpldkdyyvvrepgqspif
wyapeslsdnifsrqsdvwsfgvvlyelftycdkscspsaeflrmmgserdvpalsrlle
lleegqrlpappacpaevhelmklcwapspqdrpsfsalgpqldmlws

    Sequence, based on observed residues (ATOM records): (download) 
    >3zepA (A:)
ptifeerhlkyisqlgkgnfgsvelcrydplgdntgalvavkqlqhsgpdqqrdfqreiq
ilkalhsdfivkyrgvsyslrlvmeylpsgclrdflqrhrarldasrlllyssqickgme
ylgsrrcvhrdlaarnilveseahvkiadfglakllpldkdyyvvrepgqspifwyapes
lsdnifsrqsdvwsfgvvlyelftycdkscspsaeflrmmgspalsrllelleegqrlpa
ppacpaevhelmklcwapspqdrpsfsalgpqldml

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3zepB (B:)
dptifeerhlkyisqlgkgnfgsvelcrydplgdntgalvavkqlqhsgpdqqrdfqrei
qilkalhsdfivkyrgvsygpgrqslrlvmeylpsgclrdflqrhrarldasrlllyssq
ickgmeylgsrrcvhrdlaarnilveseahvkiadfglakllpldkdyyvvrepgqspif
wyapeslsdnifsrqsdvwsfgvvlyelftycdkscspsaeflrmmgserdvpalsrlle
lleegqrlpappacpaevhelmklcwapspqdrpsfsalgpqldmlws

    Sequence, based on observed residues (ATOM records): (download) 
    >3zepB (B:)
ptifeerhlkyisqlgkgsvelcrydplgdntgalvavkqlqhsgpdqqrdfqreiqilk
alhsdfivkyrgvsyslrlvmeylpsgclrdflqrhrarldasrlllyssqickgmeylg
srrcvhrdlaarnilveseahvkiadfglakllpldkdyyvvrspifwyapeslsdnifs
rqsdvwsfgvvlyelftycdkscspsaeflrmmgpalsrllelleegqrlpappacpaev
helmklcwapspqdrpsfsalgpqldmlws

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3zepC (C:)
dptifeerhlkyisqlgkgnfgsvelcrydplgdntgalvavkqlqhsgpdqqrdfqrei
qilkalhsdfivkyrgvsygpgrqslrlvmeylpsgclrdflqrhrarldasrlllyssq
ickgmeylgsrrcvhrdlaarnilveseahvkiadfglakllpldkdyyvvrepgqspif
wyapeslsdnifsrqsdvwsfgvvlyelftycdkscspsaeflrmmgserdvpalsrlle
lleegqrlpappacpaevhelmklcwapspqdrpsfsalgpqldmlws

    Sequence, based on observed residues (ATOM records): (download) 
    >3zepC (C:)
ptifeerhlkyisqlgkgsvelcrydplgdntgalvavkqlqhsgpdqqrdfqreiqilk
alhsdfivkyrgvsygslrlvmeylpsgclrdflqrhrarldasrlllyssqickgmeyl
gsrrcvhrdlaarnilveseahvkiadfglakllpldkdyyvvreqspifwyapeslsdn
ifsrqsdvwsfgvvlyelftycdkscspsaeflrmmgserdvpalsrllelleegqrlpa
ppacpaevhelmklcwapspqdrpsfsalgpqldmlws

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3zepD (D:)
dptifeerhlkyisqlgkgnfgsvelcrydplgdntgalvavkqlqhsgpdqqrdfqrei
qilkalhsdfivkyrgvsygpgrqslrlvmeylpsgclrdflqrhrarldasrlllyssq
ickgmeylgsrrcvhrdlaarnilveseahvkiadfglakllpldkdyyvvrepgqspif
wyapeslsdnifsrqsdvwsfgvvlyelftycdkscspsaeflrmmgserdvpalsrlle
lleegqrlpappacpaevhelmklcwapspqdrpsfsalgpqldmlws

    Sequence, based on observed residues (ATOM records): (download) 
    >3zepD (D:)
ptifeerhlkyisqlgkgnfgsvelcrydplgdntgalvavkqlqhsgpdqqrdfqreiq
ilkalhsdfivkyrgvsygslrlvmeylpsgclrdflqrhrarldasrlllyssqickgm
eylgsrrcvhrdlaarnilveseahvkiadfglakllpldkdyyvvrespifwyapesls
dnifsrqsdvwsfgvvlyelftycdkscspsaeflrmmgpalsrllelleegqrlpappa
cpaevhelmklcwapspqdrpsfsalgpqldmlw