PDB entry 3zbf

View 3zbf on RCSB PDB site
Description: Structure of Human ROS1 Kinase Domain in Complex with Crizotinib
Class: transferase
Keywords: transferase, tyrosine kinase
Deposited on 2012-11-08, released 2013-06-12
The last revision prior to the SCOPe 2.03 freeze date was dated 2013-07-03, with a file datestamp of 2013-06-28.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.236
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: proto-oncogene tyrosine-protein kinase ros
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d3zbfa_
  • Heterogens: VGH, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3zbfA (A:)
mahhhhhhdygipttenlyfqgsienlpafprekltlrlllgsgafgevyegtavdilgv
gsgeikvavktlkkgstdqekieflkeahlmskfnhpnilkqlgvcllnepqyiilelme
ggdlltylrkarmatfygplltlvdlvdlcvdiskgcvylermhfihrdlaarnclvsvk
dytsprivkigdfglardiykndyyrkrgegllpvrwmapeslmdgifttqsdvwsfgil
iweiltlghqpypahsnldvlnyvqtggrlepprncpddlwnlmtqcwaqepdqrptfhr
iqdqlqlfrnfflnsiyksrde

    Sequence, based on observed residues (ATOM records): (download) 
    >3zbfA (A:)
ienlpafprekltlrlllgsgevyegtavdilgvgsgeikvavktlkkgstdqekieflk
eahlmskfnhpnilkqlgvcllnepqyiilelmeggdlltylrkarmatfygplltlvdl
vdlcvdiskgcvylermhfihrdlaarnclvsvkdytsprivkigdfglardiylpvrwm
apeslmdgifttqsdvwsfgiliweiltlghqpypahsnldvlnyvqtggrlepprncpd
dlwnlmtqcwaqepdqrptfhriqdqlqlfrnfflnsiyksr