PDB entry 3wzj

View 3wzj on RCSB PDB site
Description: CRYSTAL STRUCTURE OF HUMAN MPS1 CATALYTIC DOMAIN IN COMPLEX WITH 4-(6-(cyclohexylamino)-8-(((tetrahydro-2H-pyran-4-yl)methyl)amino)imidazo[1,2-b]pyridazin-3-yl)-N-cyclopropylbenzamide
Class: transferase
Keywords: TRANSFERASE, ATP Binding, Phosphorylation
Deposited on 2014-09-29, released 2015-02-11
The last revision prior to the SCOPe 2.06 freeze date was dated 2015-02-11, with a file datestamp of 2015-02-06.
Experiment type: XRAY
Resolution: 2.75 Å
R-factor: 0.227
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dual specificity protein kinase TTK
    Species: Homo sapiens [TaxId:9606]
    Gene: TTK, MPS1, MPS1L1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3wzja_
  • Heterogens: O43, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3wzjA (A:)
mecisvkgriysilkqigsggsskvfqvlnekkqiyaikyvnleeadnqtldsyrneiay
lnklqqhsdkiirlydyeitdqyiymvmecgnidlnswlkkkksidpwerksywknmlea
vhtihqhgivhsdlkpanflivdgmlklidfgianqmqpdttsvvkdsqvgtvnymppea
ikdmsssrengkskskispksdvwslgcilyymtygktpfqqiinqisklhaiidpnhei
efpdipekdlqdvlkcclkrdpkqrisipellahpyvqiqthpvnqmakgtteemkyvlg
qlvglnlvprgsaaghhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3wzjA (A:)
ecisvkgriysilkqigsggsskvfqvlnekkqiyaikyvnleeadnqtldsyrneiayl
nklqqhsdkiirlydyeitdqyiymvmecgnidlnswlkkkksidpwerksywknmleav
htihqhgivhsdlkpanflivdgmlklidfgianqmqpdgtvnymppeaikdmispksdv
wslgcilyymtygktpfqqiinqisklhaiidpnheiefpdipekdlqdvlkcclkrdpk
qrisipellahpyvqiq