PDB entry 3wyy

View 3wyy on RCSB PDB site
Description: CRYSTAL STRUCTURE OF HUMAN MPS1 CATALYTIC DOMAIN IN COMPLEX WITH (E)-3-(4-((6-(((3s,5s,7s)-adamantan-1-yl)amino)-4-amino-5-cyanopyridin-2-yl)amino)-2-(cyanomethoxy)phenyl)-N-(2-methoxyethyl)acrylamide
Class: transferase
Keywords: KINASE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, INHIBITOR COMPLEX, ATP Binding
Deposited on 2014-09-10, released 2015-04-08
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-22, with a file datestamp of 2017-11-17.
Experiment type: XRAY
Resolution: 3.05 Å
R-factor: N/A
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dual specificity protein kinase TTK
    Species: Homo sapiens [TaxId:9606]
    Gene: TTK, MPS1, MPS1L1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3wyya_
  • Heterogens: O17

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3wyyA (A:)
mecisvkgriysilkqigsggsskvfqvlnekkqiyaikyvnleeadnqtldsyrneiay
lnklqqhsdkiirlydyeitdqyiymvmecgnidlnswlkkkksidpwerksywknmlea
vhtihqhgivhsdlkpanflivdgmlklidfgianqmqpdttsvvkdsqvgtvnymppea
ikdmsssrengkskskispksdvwslgcilyymtygktpfqqiinqisklhaiidpnhei
efpdipekdlqdvlkcclkrdpkqrisipellahpyvqiqthpvnqmakgtteemkyvlg
qlvglnlvprgsaaghhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3wyyA (A:)
ecisvkgriysilkqigsggsskvfqvlnekkqiyaikyvnleeadnqtldsyrneiayl
nklqqhsdkiirlydyeitdqyiymvmecgnidlnswlkkkksidpwerksywknmleav
htihqhgivhsdlkpanflivdgmlklidfgianqmqpgtvnymppeaikdmsispksdv
wslgcilyymtygktpfqqiinqisklhaiidpnheiefpdipekdlqdvlkcclkrdpk
qrisipellahpyvqiqt